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Alessandra Agresti
Researcher at Vita-Salute San Raffaele University
Publications - 53
Citations - 5219
Alessandra Agresti is an academic researcher from Vita-Salute San Raffaele University. The author has contributed to research in topics: Chromatin & DNA. The author has an hindex of 26, co-authored 52 publications receiving 4699 citations. Previous affiliations of Alessandra Agresti include Università telematica San Raffaele & University of Milan.
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Journal ArticleDOI
Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion
Tiziana Bonaldi,Fabio Talamo,Paola Scaffidi,Denise Ferrera,Annalisa Porto,Angela Bachi,Anna Rubartelli,Alessandra Agresti,Marco Bianchi +8 more
TL;DR: It is shown here that in all cells HMGB1 shuttles actively between the nucleus and cytoplasm, and secreted when monocytic cells receive an appropriate second signal.
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Glycyrrhizin binds to high-mobility group box 1 protein and inhibits its cytokine activities.
Luca Mollica,Francesco De Marchis,Andrea Spitaleri,Corrado Dallacosta,Danilo Pennacchini,Moreno Zamai,Alessandra Agresti,Lisa Trisciuoglio,Giovanna Musco,Marco Bianchi,Marco Bianchi +10 more
TL;DR: Glycyrrhizin, a natural anti-inflammatory and antiviral triterpene in clinical use, inhibits HMGB1 chemoattractant and mitogenic activities, and has a weak inhibitory effect on its intranuclear DNA-binding function.
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HMG proteins: dynamic players in gene regulation and differentiation.
Marco Bianchi,Alessandra Agresti +1 more
TL;DR: High mobility group proteins are, after histones, the second most abundant chromatin proteins and exert global genomic functions in establishing active or inactive chromatin domains and contribute to the fine tuning of transcription in response to rapid environmental changes.
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The double life of HMGB1 chromatin protein: architectural factor and extracellular signal
Susanne Müller,Paola Scaffidi,Bernard Degryse,Tiziana Bonaldi,Lorenza Ronfani,Alessandra Agresti,Monica Beltrame,Marco Bianchi +7 more
TL;DR: The High Mobility Group Box (HMGB) chromosomal proteins have been known and studied for a long time, but they also have an extracellular function, which will be the prime focus of this short review.
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HMGB proteins and gene expression.
Alessandra Agresti,Marco Bianchi +1 more
TL;DR: It is argued that HMGBs fluidize chromatin - an action that appears opposite to that of histone H1, which helps transcription factors and other nuclear proteins bind to their cognate sites by bending the DNA molecule.