G
Giovanna Musco
Researcher at Vita-Salute San Raffaele University
Publications - 94
Citations - 5927
Giovanna Musco is an academic researcher from Vita-Salute San Raffaele University. The author has contributed to research in topics: Protein structure & PHD finger. The author has an hindex of 33, co-authored 86 publications receiving 5237 citations. Previous affiliations of Giovanna Musco include National Institute for Medical Research & University of Tartu.
Papers
More filters
Journal ArticleDOI
Glycyrrhizin binds to high-mobility group box 1 protein and inhibits its cytokine activities.
Luca Mollica,Francesco De Marchis,Andrea Spitaleri,Corrado Dallacosta,Danilo Pennacchini,Moreno Zamai,Alessandra Agresti,Lisa Trisciuoglio,Giovanna Musco,Marco Bianchi,Marco Bianchi +10 more
TL;DR: Glycyrrhizin, a natural anti-inflammatory and antiviral triterpene in clinical use, inhibits HMGB1 chemoattractant and mitogenic activities, and has a weak inhibitory effect on its intranuclear DNA-binding function.
Journal ArticleDOI
A novel role for HMGB1 in TLR9-mediated inflammatory responses to CpG-DNA.
Stanimir S. Ivanov,Ana M. Dragoi,Xin Wang,Corrado Dallacosta,Jennifer Louten,Giovanna Musco,Giovanni Sitia,George S. Yap,Yinsheng Wan,Christine A. Biron,Marco Bianchi,Haichao Wang,Wen-Ming Chu +12 more
TL;DR: The DNA-binding protein HMGB1 shuttles in and out of immune cells and regulates inflammatory responses to CpG-DNA.
A novel role for HMGB1 in TLR9-mediated inflammatory responses to CpG-DNA Running title: Mechanism of TLR9 activation
Wen-Ming Chu,Giovanni Sitia,George S. Yap,Yinsheng Wan,Christine A. Biron,Marco Bianchi,Haichao Wang,Stanimir S. Ivanov,Ana-Maria Dragoi,Xin Wang,Corrado Dallacosta,Jennifer Louten,Giovanna Musco +12 more
TL;DR: In this paper, the authors identified HMGB1 as a CpG-ODN-binding protein, which interacts and pre-associates with TLR9 in the endoplasmic reticulum-Golgi intermediate compartment (ERGIC), and hastens TLR 9's redistribution to early endosomes in response to CpGs-ODNs.
Journal ArticleDOI
Defective glucose metabolism in polycystic kidney disease identifies a new therapeutic strategy
Isaline Rowe,Marco Chiaravalli,Valeria Mannella,Valeria Ulisse,Giacomo Quilici,Monika Pema,Xuewen W Song,Hangxue Xu,Hangxue Xu,Silvia Mari,Feng Qian,Feng Qian,York Pei,Giovanna Musco,Alessandra Boletta +14 more
TL;DR: Data indicate that defective glucose metabolism is intimately involved in the pathobiology of ADPKD, and provides a strong rationale for a new therapeutic strategy using existing drugs, either individually or in combination.
Journal ArticleDOI
Solution NMR of proteins within polyacrylamide gels: diffusional properties and residual alignment by mechanical stress or embedding of oriented purple membranes.
TL;DR: The diffusive properties of biomacromolecules within the aqueous phase of polyacrylamide gels are described and methods are applied to derive residual dipolar couplings for human HIV-1 Nef and ubiquitin.