A
Alessandra Bonamore
Researcher at Sapienza University of Rome
Publications - 58
Citations - 1488
Alessandra Bonamore is an academic researcher from Sapienza University of Rome. The author has contributed to research in topics: Heme & Ferritin. The author has an hindex of 21, co-authored 54 publications receiving 1289 citations.
Papers
More filters
Journal ArticleDOI
The X-ray structure of ferric Escherichia coli flavohemoglobin reveals an unexpected geometry of the distal heme pocket.
TL;DR: Surprisingly, imidazole, cyanide, and azide binding profiles at equilibrium are not accounted for by a single site titration curve but are biphasic and strongly suggest the presence of two distinct conformers within the liganded species.
Journal ArticleDOI
Structural basis of enzymatic (S)-norcoclaurine biosynthesis.
Andrea Ilari,Stefano Franceschini,Alessandra Bonamore,Fabio Arenghi,Bruno Botta,Alberto Macone,Alessandra Pasquo,Luca Bellucci,Alberto Boffi +8 more
TL;DR: The geometry of the amino acid side chains with respect to the substrates reveals the structural determinants that govern the mechanism of the stereoselective Pictet-Spengler cyclization, thus establishing an excellent foundation for the understanding of the finer details of the catalytic process.
Journal ArticleDOI
Flavohemoglobin: structure and reactivity.
TL;DR: The alkylhydroperoxide reductase activity taken together with the unique lipid‐binding properties of HMP suggests that this flavoHb may be involved in the repair of the lipid membrane oxidative damage generated during oxidative/nitrosative stress.
Journal ArticleDOI
Sulfide binding properties of truncated hemoglobins.
Francesco P. Nicoletti,Alessandra Comandini,Alessandra Bonamore,Leonardo Boechi,Fernando Martín Boubeta,Alessandro Feis,Giulietta Smulevich,Alberto Boffi +7 more
TL;DR: Interestingly, the triple Tf-trHb mutant bearing only Phe residues in the relevant B10, G8, and CD1 positions is endowed with a higher overall affinity for sulfide characterized by a very fast second-order rate constant and 2 order of magnitude faster kinetics of sulfide release with respect to the wild-type protein.
Journal ArticleDOI
Horseradish peroxidase in ionic liquids: Reactions with water insoluble phenolic substrates
Simona Sgalla,Giancarlo Fabrizi,Sandro Cacchi,Alberto Macone,Alessandra Bonamore,Alberto Boffi +5 more
TL;DR: In this paper, the reactivity of horseradish peroxidase with water insoluble phenolic compounds has been studied in 1-butyl-3-methylimidazolium tetrafluoroborate ([BMIM][BF 4 ])/water mixtures.