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Alessandra Compagnone
Researcher at University of Turin
Publications - 17
Citations - 1022
Alessandra Compagnone is an academic researcher from University of Turin. The author has contributed to research in topics: Epithelial–mesenchymal transition & Hepatic stellate cell. The author has an hindex of 11, co-authored 17 publications receiving 926 citations.
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Journal ArticleDOI
Redox mechanisms switch on hypoxia-dependent epithelial-mesenchymal transition in cancer cells.
Stefania Cannito,Erica Novo,Alessandra Compagnone,Lorenzo Valfrè di Bonzo,Chiara Busletta,E. Zamara,Claudia Paternostro,Davide Povero,Andrea Bandino,Francesca Bozzo,Carlo Cravanzola,Vittoria Bravoco,Sebastiano Colombatto,Maurizio Parola +13 more
TL;DR: It is indicated that in cancer cells, early redox mechanisms can switch on hypoxia-dependent EMT programme whereas increased invasiveness is sustained by late and HIF-1alpha-dependent release of VEGF.
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Proangiogenic cytokines as hypoxia-dependent factors stimulating migration of human hepatic stellate cells.
Erica Novo,Stefania Cannito,E. Zamara,Lorenzo Valfrè di Bonzo,Alessandra Caligiuri,Carlo Cravanzola,Alessandra Compagnone,Sebastiano Colombatto,Fabio Marra,Massimo Pinzani,Maurizio Parola +10 more
TL;DR: Data presented herein suggest that VEGF and Ang-1 may contribute to fibrogenesis by acting as hypoxia-inducible, autocrine, and paracrine factors able to recruit myofibroblast-like cells.
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Intracellular reactive oxygen species are required for directional migration of resident and bone marrow-derived hepatic pro-fibrogenic cells
Erica Novo,Chiara Busletta,Lorenzo Valfrè di Bonzo,Davide Povero,Claudia Paternostro,Katia Mareschi,Ivana Ferrero,Ezio David,C. Bertolani,Alessandra Caligiuri,Stefania Cannito,Elena Tamagno,Alessandra Compagnone,Sebastiano Colombatto,Fabio Marra,Franca Fagioli,Massimo Pinzani,Maurizio Parola +17 more
TL;DR: Intracellular generation of ROS, through activation of specific signaling pathways, is a critical event for directional migration of HSC/MFs and MSCs.
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Cobalt induces oxidative stress in isolated liver mitochondria responsible for permeability transition and intrinsic apoptosis in hepatocyte primary cultures
Valentina Battaglia,Alessandra Compagnone,Andrea Bandino,Marcantonio Bragadin,Carlo Alberto Rossi,Filippo Zanetti,Sebastiano Colombatto,Maria Angelica Grillo,Antonio Toninello +8 more
TL;DR: Observations allow us to state that, in the presence of calcium, Co(2+) is an inducer of apoptosis triggered by mitochondrial oxidative stress.
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The biphasic nature of hypoxia-induced directional migration of activated human hepatic stellate cells.
Erica Novo,Davide Povero,Chiara Busletta,Claudia Paternostro,Lorenzo Valfrè di Bonzo,Stefania Cannito,Alessandra Compagnone,Andrea Bandino,Fabio Marra,Sebastiano Colombatto,Ezio David,Massimo Pinzani,Maurizio Parola +12 more
TL;DR: Investigation of early and delayed signalling mechanisms involved in hypoxia‐induced migration of human HSC/MFs indicates an early, mitochondrial‐dependent ROS‐mediated activation of ERK and JNK, followed by a delayed‐ and HIF‐1α‐dependent up‐regulation and release of VEGF.