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Alex J Eustace
Researcher at Dublin City University
Publications - 56
Citations - 991
Alex J Eustace is an academic researcher from Dublin City University. The author has contributed to research in topics: Breast cancer & Trastuzumab. The author has an hindex of 14, co-authored 45 publications receiving 804 citations. Previous affiliations of Alex J Eustace include Royal College of Surgeons in Ireland & Beaumont Hospital.
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Journal ArticleDOI
In vitro Development of Chemotherapy and Targeted Therapy Drug-Resistant Cancer Cell Lines: A Practical Guide with Case Studies.
Martina McDermott,Alex J Eustace,Steven Busschots,Laura Breen,John Crown,Martin Clynes,Norma O'Donovan,Britta K. Stordal +7 more
TL;DR: Key decisions to be made prior to starting resistant cell line development are discussed; the choice of parent cell line, dose of selecting agent, treatment interval, and optimizing the dose of drug for theparent cell line.
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The 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, simvastatin, lovastatin and mevastatin inhibit proliferation and invasion of melanoma cells
TL;DR: The results suggest that statin treatment is unlikely to prevent melanoma development at standard doses, however, higher doses of statins may have a role to play in adjuvant therapy by inhibiting growth and invasion of melanoma cells.
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Preclinical evaluation of dasatinib, a potent Src kinase inhibitor, in melanoma cell lines.
TL;DR: Dasatinib has both anti-proliferative and anti-invasive effects in melanoma cells and combined with chemotherapy may have clinical benefit in the treatment of malignant melanoma.
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HER2-family signalling mechanisms, clinical implications and targeting in breast cancer
Naomi Elster,Denis M. Collins,Sinead Toomey,John Crown,Alex J Eustace,Bryan T. Hennessy,Bryan T. Hennessy +6 more
TL;DR: With the rapidly expanding understanding of HER2 signalling mechanisms along with the repertoire of HER family and other targeted therapies, it is likely that the near future holds further dramatic improvements to the prognosis of women with HER2-positive BC.
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Metabolomic studies of human lung carcinoma cell lines using in vitro (1)H NMR of whole cells and cellular extracts.
Michael Gottschalk,Galya Ivanova,Galya Ivanova,Dennis Collins,Alex J Eustace,Robert O'Connor,Dermot F. Brougham +6 more
TL;DR: For whole cells, it was found that the statistically significant causes of spectral variation were an increase in the choline and a decrease in the methylene mobile lipid 1H resonance intensities, which correlate with knowledge of the level of resistance displayed by the different cells.