A
Alex Toftgaard Nielsen
Researcher at Technical University of Denmark
Publications - 103
Citations - 6694
Alex Toftgaard Nielsen is an academic researcher from Technical University of Denmark. The author has contributed to research in topics: Gene & Fermentation. The author has an hindex of 30, co-authored 94 publications receiving 5792 citations. Previous affiliations of Alex Toftgaard Nielsen include Stanford University & Genencor.
Papers
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Journal ArticleDOI
Quantification of biofilm structures by the novel computer program COMSTAT.
Arne Heydorn,Alex Toftgaard Nielsen,Morten Hentzer,Claus Sternberg,Michael Givskov,Bjarne Kjær Ersbøll,Søren Molin +6 more
TL;DR: Analysis of biofilms of P. aureofaciens growing on 0.03 mM, 0.1 mM or 0.5 mM citrate minimal media showed that mean biofilm thickness increased with increasing citrate concentration, whereas surface to volume ratio increased with higher citrate concentrations.
Journal ArticleDOI
The Vibrio cholerae chitin utilization program
Karin L. Meibom,Xibing B. Li,Alex Toftgaard Nielsen,Cheng-Yen Wu,Saul Roseman,Gary K. Schoolnik +5 more
TL;DR: This work shows that ChiS, a sensor histidine kinase, regulates expression of the (GlcNAc)(2-6) gene set, and identifies three sets of differentially regulated genes that confer a significant growth advantage to V. cholerae on a chitin surface.
Journal ArticleDOI
Distribution of Bacterial Growth Activity in Flow-Chamber Biofilms
Claus Sternberg,Bjarke Bak Christensen,Tove Johansen,Alex Toftgaard Nielsen,Jens Bo Andersen,Michael Givskov,Søren Molin +6 more
TL;DR: It is demonstrated that individual cells of a toluene-degrading P. putida strain growing in a benzyl alcohol-supplemented biofilm have different levels of growth activity which develop as the biofilm gets older.
Book ChapterDOI
Molecular tools for study of biofilm physiology.
Bjarke Bak Christensen,Claus Sternberg,Jens Bo Andersen,Robert J. Palmer,Alex Toftgaard Nielsen,Michael Givskov,Søren Molin +6 more
TL;DR: The ribosome number is a reliable indicator of growth rate in bacteria growing in balanced growth and has been used as a standard for growth rates in biofilm-embedded bacteria as well.
Journal ArticleDOI
Identification of a Novel Group of Bacteria in Sludge from a Deteriorated Biological Phosphorus Removal Reactor
Alex Toftgaard Nielsen,Wen Tso Liu,Wen Tso Liu,Carlos D. M. Filipe,Leslie Grady,Søren Molin,David A. Stahl +6 more
TL;DR: The microbial diversity of a deteriorated biological phosphorus removal reactor was investigated by methods not requiring direct cultivation and suggested a novel group of the gamma subclass of the Proteobacteria with no close relationship to any previously described species.