Gary K. Schoolnik

TL;DR: In this article, the differences between M. tuberculosis, M. bovis, and Bacille Calmette-Guerin (BCG) vaccines were studied by performing comparative hybridization experiments on a DNA microarray.

TL;DR: The microbial transcriptome served as a bioprobe of the MTB phagosomal environment, showing it to be nitrosative, oxidative, functionally hypoxic, carbohydrate poor, and capable of perturbing the pathogen's cell envelope.

TL;DR: Analysis of M. tuberculosis isolates from all patients reported to the tuberculosis registry in San Francisco during 1991 and 1992 confirmed that poorly compliant patients with infectious tuberculosis have a substantial adverse effect on the control of this disease.

TL;DR: There should be heightened surveillance for tuberculosis in facilities where HIV-infected persons live, and investigation of contacts must be undertaken promptly and be focused more broadly than is usual.

TL;DR: It is shown that O2 and low, nontoxic concentrations of NO competitively modulate the expression of a 48-gene regulon, which is expressed in vivo and prepares bacilli for survival during long periods of in vitro dormancy, and leads to a model postulating that, within granulomas, inhibition of respiration by NO production and O2 limitation constrains M. tuberculosis replication rates in persons with latent tuberculosis.