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Alex Yee-Chen Huang
Researcher at Case Western Reserve University
Publications - 107
Citations - 7986
Alex Yee-Chen Huang is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 35, co-authored 98 publications receiving 7137 citations. Previous affiliations of Alex Yee-Chen Huang include University of Chicago & National Institutes of Health.
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Journal ArticleDOI
Role of bone marrow-derived cells in presenting MHC class I-restricted tumor antigens
Alex Yee-Chen Huang,Paul Golumbek,Mojgan Ahmadzadeh,Elizabeth M. Jaffee,Drew M. Pardoll,Hyam I. Levitsky +5 more
TL;DR: MHC class I-restricted antigens are efficiently transferred in vivo to bone marrow-derived antigen-presenting cells, which suggests that human leukocyte antigen matching may be less critical in the application of tumor vaccines than previously thought.
Journal ArticleDOI
Chemokines enhance immunity by guiding naive CD8 + T cells to sites of CD4 + T cell–dendritic cell interaction
Flora Castellino,Alex Yee-Chen Huang,Grégoire Altan-Bonnet,Grégoire Altan-Bonnet,Sabine Stoll,Sabine Stoll,Clemens Scheinecker,Clemens Scheinecker,Ronald N. Germain +8 more
TL;DR: It is demonstrated that after immunization but before antigen recognition, naive CD8+ T cells in immunogen-draining lymph nodes upregulate the chemokine receptor CCR5, permitting these cells to be attracted to sites of antigen-specific dendritic cell–CD4+ T cell interaction where the cognate chemokines CCL3 and CCL4 are produced.
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Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TLR engagement
TL;DR: Findings support a model in which epithelial cell TLR signaling upon exposure to microbial stimuli induces active DC sampling of the gut lumen at sites distant from organized lymphoid tissues.
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Extrafollicular Activation of Lymph Node B Cells by Antigen-Bearing Dendritic Cells
TL;DR: It is shown that, after exiting high-endothelial venules and before entry into lymph node follicles, B cells survey locally concentrated dendritic cells, suggesting a possible role for antigen-specific B-DC interactions in promoting T cell–dependent antibody responses in vivo.
Journal ArticleDOI
The immunodominant major histocompatibility complex class I-restricted antigen of a murine colon tumor derives from an endogenous retroviral gene product.
Alex Yee-Chen Huang,Pamela H. Gulden,Amina S. Woods,Matthew C. Thomas,Caryn D. Tong,Wei Wang,Victor H. Engelhard,Gary R. Pasternack,Robert J. Cotter,Donald F. Hunt,Drew M. Pardoll,Elizabeth M. Jaffee +11 more
TL;DR: Adoptive transfer with CTL lines specific for this antigen demonstrated that this epitope represents a potent tumor rejection antigen, providing evidence for a unique class of shared immunodominant tumor associated antigens as targets for antitumor immunity.