Hai Qi

TL;DR: It is shown that SAP deficiency selectively impairs the ability of CD4+ T cells to stably interact with cognate B cells but not antigen-presenting dendritic cells, which results in a failure of antigen-specific B cells to receive adequate levels of contact-dependent T-cell help to expand normally.

TL;DR: It is shown that, after exiting high-endothelial venules and before entry into lymph node follicles, B cells survey locally concentrated dendritic cells, suggesting a possible role for antigen-specific B-DC interactions in promoting T cell–dependent antibody responses in vivo.

TL;DR: A subset of exhausted CD8+ T cells expressing the chemokine receptor CXCR5 has a critical role in the control of viral replication in mice that were chronically infected with lymphocytic choriomeningitis virus (LCMV).

TL;DR: The results reveal insight into the dynamic regulation of T cell:B cell interactions and identify SLAM family members as critical components of sustained T cell-B cell adhesion required for productive humoral immunity.

TL;DR: It is shown that ICOS directly controls follicular recruitment of activated T-helper cells in mice, and this effect is independent from ICOS ligand (ICOSL)-mediated co-stimulation provided by antigen-presenting dendritic cells or cognate B cells, and does not rely on Bcl6-mediated programming as an intermediate step.