A
Alexander F. Lovejoy
Researcher at Stanford University
Publications - 20
Citations - 3245
Alexander F. Lovejoy is an academic researcher from Stanford University. The author has contributed to research in topics: Lung cancer & RNA. The author has an hindex of 10, co-authored 17 publications receiving 2436 citations.
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Journal ArticleDOI
Integrated digital error suppression for improved detection of circulating tumor DNA
Aaron M. Newman,Alexander F. Lovejoy,Daniel M. Klass,David M. Kurtz,Jacob J. Chabon,Florian Scherer,Henning Stehr,Chih Long Liu,Scott V. Bratman,Carmen Say,Li Zhou,Justin N. Carter,Robert B. West,George W. Sledge,Joseph B. Shrager,Billy W. Loo,Joel W. Neal,Heather A. Wakelee,Maximilian Diehn,Ash A. Alizadeh +19 more
TL;DR: This work introduces an approach for integrated digital error suppression (iDES), which combines in silico elimination of highly stereotypical background artifacts with a molecular barcoding strategy for the efficient recovery of cfDNA molecules, and facilitates noninvasive variant detection across hundreds of kilobases of circulating tumor DNA.
Journal ArticleDOI
Early Detection of Molecular Residual Disease in Localized Lung Cancer by Circulating Tumor DNA Profiling
Aadel A. Chaudhuri,Jacob J. Chabon,Alexander F. Lovejoy,Aaron M. Newman,Henning Stehr,Tej D. Azad,Michael S. Khodadoust,Mohammad Shahrokh Esfahani,Chih Long Liu,Li Zhou,Florian Scherer,David M. Kurtz,Carmen Say,Justin N. Carter,D.J. Merriott,Jonathan C. Dudley,Michael S. Binkley,Leslie A. Modlin,Sukhmani K. Padda,Michael F. Gensheimer,Robert B. West,Joseph B. Shrager,Joel W. Neal,Heather A. Wakelee,Billy W. Loo,Ash A. Alizadeh,Maximilian Diehn +26 more
TL;DR: This study shows that ctDNA analysis can robustly identify posttreatment MRD in patients with localized lung cancer, identifying residual/recurrent disease earlier than standard-of-care radiologic imaging, and thus could facilitate personalized adjuvant treatment at early time points when disease burden is lowest.
Journal ArticleDOI
Circulating tumour DNA profiling reveals heterogeneity of EGFR inhibitor resistance mechanisms in lung cancer patients
Jacob J. Chabon,Andrew Simmons,Alexander F. Lovejoy,Mohammad Shahrokh Esfahani,Aaron M. Newman,Henry J. Haringsma,David M. Kurtz,Henning Stehr,Florian Scherer,Chris Karlovich,Thomas Harding,Kathleen A. Durkin,Gregory A. Otterson,W. Thomas Purcell,D. Ross Camidge,Jonathan W. Goldman,Lecia V. Sequist,Zofia Piotrowska,Heather A. Wakelee,Joel W. Neal,Ash A. Alizadeh,Maximilian Diehn +21 more
TL;DR: In this article, the authors employ CAPP-Seq ctDNA analysis to study resistance mechanisms in 43 non-small cell lung cancer (NSCLC) patients treated with the third-generation epidermal growth factor receptor (EGFR) inhibitor rociletinib.
Journal ArticleDOI
Distinct biological subtypes and patterns of genome evolution in lymphoma revealed by circulating tumor DNA.
Florian Scherer,David M. Kurtz,Aaron M. Newman,Henning Stehr,Alexander F.M. Craig,Mohammad Shahrokh Esfahani,Alexander F. Lovejoy,Jacob J. Chabon,Daniel M. Klass,Chih Long Liu,Li Zhou,Cynthia Glover,Brendan C. Visser,George A. Poultsides,Ranjana H. Advani,Lauren S. Maeda,Neel K. Gupta,Ronald Levy,Robert S. Ohgami,Christian A. Kunder,Maximilian Diehn,Ash A. Alizadeh +21 more
TL;DR: The authors demonstrated that circulating tumor DNA in the patients’ blood is suitable for this analysis, allowing for periodic monitoring of each patient without repeated invasive biopsies and facilitating individualized therapy.
Journal ArticleDOI
Transcriptome-wide mapping of pseudouridines: pseudouridine synthases modify specific mRNAs in S. cerevisiae.
TL;DR: It is established that site-specific pseudouridylation of eukaryotic mRNAs is a genetically programmed RNA modification that naturally occurs in multiple yeast transcripts via distinct mechanisms, suggesting that mRNA pseudourIDylation may provide an important novel regulatory function.