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Aadel A. Chaudhuri
Researcher at Washington University in St. Louis
Publications - 110
Citations - 9792
Aadel A. Chaudhuri is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 23, co-authored 68 publications receiving 6903 citations. Previous affiliations of Aadel A. Chaudhuri include Barnes-Jewish Hospital & Massachusetts Institute of Technology.
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Journal ArticleDOI
Determining cell type abundance and expression from bulk tissues with digital cytometry.
Aaron M. Newman,Chloé B. Steen,Chloé B. Steen,Chih Long Liu,Andrew J. Gentles,Aadel A. Chaudhuri,Florian Scherer,Michael S. Khodadoust,Mohammad Shahrokh Esfahani,Bogdan A. Luca,David F. Steiner,Maximilian Diehn,Ash A. Alizadeh +12 more
TL;DR: The utility of CIBERSORTx is evaluated in multiple tumor types, including melanoma, where single-cell reference profiles were used to dissect bulk clinical specimens, revealing cell-type-specific phenotypic states linked to distinct driver mutations and response to immune checkpoint blockade.
Journal ArticleDOI
Physiological and pathological roles for microRNAs in the immune system
TL;DR: Recent advances in understanding of both the intended functions of miRNAs in managing immune cell biology and their pathological roles when their expression is dysregulated are discussed.
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MicroRNA-155 Promotes Autoimmune Inflammation by Enhancing Inflammatory T Cell Development
Ryan M. O'Connell,Daniel Kahn,Daniel Kahn,William S. Gibson,June L. Round,Rebecca L. Scholz,Aadel A. Chaudhuri,Melissa Kahn,Dinesh S. Rao,Dinesh S. Rao,David Baltimore +10 more
TL;DR: It is shown that one aspect of miR-155 function is the promotion of T cell-dependent tissue inflammation, suggesting that miR -155 might be a promising therapeutic target for the treatment of autoimmune disorders.
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Inositol phosphatase SHIP1 is a primary target of miR-155.
TL;DR: This study unveils a molecular link between miR-155 and SHIP1 and provides evidence that repression ofSHIP1 is an important component of miR -155 biology.
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Sustained expression of microRNA-155 in hematopoietic stem cells causes a myeloproliferative disorder.
Ryan M. O'Connell,Dinesh S. Rao,Aadel A. Chaudhuri,Mark Boldin,Konstantin Taganov,John Nicoll,Ronald Paquette,David Baltimore +7 more
TL;DR: Evidence is presented of a strong but transient induction of miR-155 in mouse bone marrow after injection of bacterial lipopolysaccharide correlated with granulocyte/monocyte (GM) expansion, which implicate mi R-155 as a contributor to physiological GM expansion during inflammation and to certain pathological features associated with AML.