A
Alexander Lam
Researcher at Royal Perth Hospital
Publications - 5
Citations - 77
Alexander Lam is an academic researcher from Royal Perth Hospital. The author has contributed to research in topics: Ryanodine receptor & FKBP. The author has an hindex of 5, co-authored 5 publications receiving 67 citations. Previous affiliations of Alexander Lam include Australian National University.
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Journal ArticleDOI
Multiple actions of phi-LITX-Lw1a on ryanodine receptors reveal a functional link between scorpion DDH and ICK toxins.
Jennifer J. Smith,Irina Vetter,Richard J. Lewis,Steve Peigneur,Jan Tytgat,Alexander Lam,Esther M. Gallant,Nicole A. Beard,Paul F. Alewood,Angela F. Dulhunty +9 more
TL;DR: It is revealed that U1-LITX-Lw1a targets and activates the mammalian ryanodine receptor intracellular calcium release channel (RyR) with high (fM) potency and provides a functional link between DDH and ICK scorpion toxins, and it is shown that the C-terminal residue is crucial for the increase in full receptor openings but not for the increased in receptor subconductance opening, thereby supporting the two-binding-site hypothesis.
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Intracranial Myxoid Variant of Angiomatoid Fibrous Histiocytoma: A Case Report and Literature Review
TL;DR: A 58-year-old woman presenting with the first episode of generalized seizure due to an extra-axial lesion with homogenous contrast enhancement in the right parietal lobe is illustrated the need to consider the myxoid variant of intracranial AFH in the differential diagnosis of meningioma-like tumors.
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Association of FK506 binding proteins with RyR channels - effect of CLIC2 binding on sub-conductance opening and FKBP binding.
Spencer J. Richardson,Gregory A. Steele,Esther M. Gallant,Alexander Lam,Charles E. Schwartz,Philip G. Board,Marco G. Casarotto,Nicole A. Beard,Angela F. Dulhunty +8 more
TL;DR: The results show that FKBPs do influence RyR gating and would contribute to excess Ca2+ release in this CLIC2 RyR channelopathy.
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The Anthracycline Metabolite Doxorubicinol Abolishes RyR2 Sensitivity to Physiological Changes in Luminal Ca2+ through an Interaction with Calsequestrin
Amy D. Hanna,Alexander Lam,Chris Thekkedam,Hermia Willemse,Angela F. Dulhunty,Nicole A. Beard +5 more
TL;DR: It is suggested that doxOL and low luminal Ca2+ both disrupt the CSQ2 polymer, and that the association of the monomeric protein with the RyR2 complex shifts the increase inRyR2 activity with increasing luminal [Ca2+] away from the physiologic [Ca1+] range.
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Tension Pneumocephalus Following Bilateral Craniotomies
TL;DR: The diagnosis is clinical and radiological with the characteristic Mount Fuji sign seen on computed tomography (CT) and is a neurosurgical emergency, and early recognition and treatment are vital.