Steve Peigneur

TL;DR: This review focuses on the current status of research on neurotoxins acting on VGSC, their contribution to further unravel the structure and function of VGSC and their potential as novel lead compounds in drug development.

TL;DR: An overview of the knowledge the authors have today on the molecular pharmacology of conotoxins specifically interacting with nAChRs along with the structure–function relationship data is given.

TL;DR: This study demonstrates that APEKTx1 has the unique feature to combine the dual functionality of a potent and selective blocker of K(V)1.1 channels with that of a competitive inhibitor of trypsin.

TL;DR: It is expected that more novel cannabinoids will be discovered and forecasted as promising drug leads from diverse natural sources and species, such as animal venoms which constitute a true pharmacopeia of toxins modulating diverse targets, with astonishing affinity and selectivity.

TL;DR: The target promiscuity of a family of sea anemone toxins thus far believed to be highly selective is described for the first time, and it is shown that the homologous toxins APETx1 and APetx2 display promiscuous properties since they are also capable of recognizing NaV channels with IC50 values of 31 nM and 114 nM, respectively, causing an inhibition of the sodium conductance without affecting the inactivation.