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Alexander M. Dizhoor
Researcher at Salus University
Publications - 88
Citations - 5958
Alexander M. Dizhoor is an academic researcher from Salus University. The author has contributed to research in topics: GUCY2D & Cyclase. The author has an hindex of 42, co-authored 87 publications receiving 5606 citations. Previous affiliations of Alexander M. Dizhoor include Kresge Eye Institute & Wayne State University.
Papers
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Journal ArticleDOI
Ectopic Expression of a Microbial-Type Rhodopsin Restores Visual Responses in Mice with Photoreceptor Degeneration
Anding Bi,Jinjuan Cui,Y.–P. Ma,Elena V. Olshevskaya,Mingliang Pu,Alexander M. Dizhoor,Alexander M. Dizhoor,Zhuo-Hua Pan +7 more
TL;DR: It is demonstrated that expression of ChR2 in surviving inner retinal neurons of a mouse with photoreceptor degeneration can restore the ability of the retina to encode light signals and transmit the light signals to the visual cortex.
Journal ArticleDOI
The human photoreceptor membrane guanylyl cyclase, RetGC, is present in outer segments and is regulated by calcium and a soluble activator
Alexander M. Dizhoor,David G. Lowe,Elena V. Olshevskaya,Richard P. Laura,James B. Hurley,James B. Hurley +5 more
TL;DR: The findings indicate that RetGC is a photoreceptor-specific guanylyl cyclase which is stimulated by a retinal-specific activator and inhibited by physiologically relevant concentrations of free Ca2+.
Journal ArticleDOI
Cloning, Sequencing, and Expression of a 24-kDa Ca2+-binding Protein Activating Photoreceptor Guanylyl Cyclase
Alexander M. Dizhoor,Elena V. Olshevskaya,William J. Henzel,Susan C. Wong,John T. Stults,Irina Ankoudinova,James B. Hurley +6 more
TL;DR: It is demonstrated that p24, like GCAP, imparts Ca2+ sensitivity to photoreceptor membrane guanylyl cyclase in vitro at submicromolar concentrations and be referred to as GCAP-1.
Journal ArticleDOI
Recoverin immunoreactivity in mammalian cone bipolar cells.
TL;DR: Cell density, dendritic morphology, and axonal-field size and stratification indicate that anti-recoverin selectively strains the flat midget cone bipolar cell type observed previously in Golgi preparations.
Journal ArticleDOI
Cloning and expression of a second photoreceptor-specific membrane retina guanylyl cyclase (RetGC), RetGC-2
David G. Lowe,Alexander M. Dizhoor,Kathleen Liu,Qimin Gu,Maribeth Spencer,Richard P. Laura,Lucy Lu,James B. Hurley +7 more
TL;DR: A previously unappreciated diversity of photoreceptor GCs is revealed by screening a human retinal cDNA library at low stringency with the cytoplasmic domains from four cyclases and cloned cDNAs encoding a membrane CG most closely related to RetGC.