Alexandre Umpierrez Amaral

TL;DR: Patients affected by FAOD commonly present with hepatopathy, cardiomyopathy, skeletal myopathy and encephalopathy, suggesting that lipotoxicity may contribute to their pathogenesis.

TL;DR: The present data indicate that KIC acts as an uncoupler of oxidative phosphorylation and as a metabolic inhibitor possibly through its inhibitory effect on alpha-ketoglutarate dehydrogenase activity, while Leu acts asA metabolic inhibitor.

TL;DR: The data indicate that Phe elicits oxidative stress in the hippocampus, a structure mainly involved with learning/memory, and also in the cerebral cortex, which is severely damaged in PKU patients, and it is presumed that this pathomechanism may be involved at least in part in the severe cognitive deficit and in the characteristic cortical atrophy observed in this disorder.

TL;DR: In this article, the authors compared the performance of ultrasound-assisted and conventional extractions of red araca peel and showed promising results for the ultrasound assisted and conventional extraction, respectively.

TL;DR: Investigation of in-vitro effects of MMA and PA on important parameters of lipid and protein oxidative damage and on the production of reactive species in synaptosomes from cerebrum of developing rats demonstrated the participation of neuronal cells in MMA-elicited oxidative damage.