Levy Kopelovich

TL;DR: Although no single mouse model recapitulated all the expression features of a given human subtype, these shared expression features provide a common framework for an improved integration of murine mammary tumor models with human breast tumors.

TL;DR: The current preclinical and mechanistic data available and resveratrol's anticancer effects are assessed to support its potential as an anticancer agent in human populations are discussed.

TL;DR: The preponderance of inactivating mutations in RNF43 unequivocally establish it as a suppressor of both IPMNs and MCNs, highlighting the essential role of ubiquitin ligases in these neoplasms and have important implications for the diagnosis and treatment of patients with cystic tumors.

TL;DR: There is increasing evidence that resveratrol exhibits pro-oxidant activity under certain experimental conditions, causing oxidative DNA damage that may lead to cell cycle arrest or apoptosis.

TL;DR: Next-generation sequencing is used, including whole-genome and whole-exome analyses, and heterozygous, constitutional, ataxia telangiectasia mutated (ATM) gene mutations in 2 kindreds with familial pancreatic cancer are identified, indicating that inherited ATM mutations play an important role in familial Pancreatic cancer predisposition.