Alfredo Caturano

TL;DR: National and international guidelines should consider its inclusion in their updates, and the deployment of device and digital application used to increase screening of individuals and monitor progression of retinal disease needs to be easily accessible to general practitioners.

TL;DR: In this paper, the authors consider the risk of metabolic syndrome as a risk factor for cardiovascular disease, regardless of age, sex, smoking habit, cholesterolemia, and other elements of MS, and suggest that lifestyle modifications (diet, physical exercise, and weight loss) determine an improvement in IR, MS and both clinical and histologic liver picture.

TL;DR: In this paper, a review of metformin's beneficial effects on endothelium-dependent vascular response in type 2 diabetes patients is presented, which could preempt development of atherosclerosis.

TL;DR: The role of diet, intestinal microbiota, genetic and epigenetic factors, low-degree chronic systemic inflammation, mitochondrial dysfunction, and endoplasmic reticulum stress on NAFLD have been addressed and its direct link with type 2 diabetes have been discussed.

TL;DR: Correcting cardiorenal risk factors, metabolic adjustments ameliorating myocardial substrate utilization, and optimization of ventricular loading conditions through effects on diuresis, natriureis, and vascular function appear to be the main underlying mechanisms for the observed cardi Lorenal protection.