CLINICAL NEUROSURGERY Edited by Barnes Wordall. Vol. 18. (Pp. 557; illustrated; £8 25.) Churchill Livingstone: Edinburgh. 1971. CLINICAL NEUROSURGERY Edited by G. T. Tindall. Vol. 19. (Pp. 598; illustrated; £12.) Churchill Livingstone: Edinburgh. 1972. The Congress of Neurosurgeons began in 1951 on the initiative of a group of younger neurosurgeons. In the last 20 years its membership has grown from 69 to over 1,000, but it has retained its original intentions and virility by a constitution which ensured that the office bearers and organizers were always young men. Residents in training are encouraged to join, financial concessions make it possible for them to attend meetings, and these are organized as an educational exercise, by inviting established authorities to give lectures on selected topics, chosen to provide a balanced programme. As a result Clinical Neurosurgery is a valuable volume which all neurosurgeons look forward to each year; it is in quite a different class from the usual conference tome, full of brief and unconnected papers of widely varying quality. As the title suggests Clinical Neurosurgery includes excellent clinical reviews but the two recent volumes include also a section of seminars on fundamental research-in volume 18 on coma and sleep, in volume 19 on basic mechanisms of memory. It is also the custom to invite a senior neurosurgical citizen as guest of honour and his two or three papers afford an opportunity for historical and philosophical reflections as well as an experienced perspective on clinical and experimental work. Add to this the refreshing presidential address, from one of the (angry?) young men of neurosurgery and it will be clear that these volumes really do include something of interest for every neurosurgeon, whatever his own interests or prejudices. It is a relief to be able so warmly to recommend these books, when the question posed by so many other books is whether anyone would really want to read them. The most recent volume has a more consistent theme than former ones, and that is 'head injury'. It includes papers on mechanisms as revealed by animal experiment and by a pathologist who visited the scene of the accident before examining the brains of head injury fatalities. There are chapters on engineering and socio-psychological aspects of accident prevention, as well as down to earth clinical accounts of metabolic disorders, testing for acoustic vestibular 36 damage, and aspects of prognosis. This is a significant contribution to the literature on head injury.

https://jnnp.bmj.com/content/jnnp/37/3/361.3.full.pdf

The working brain (an introduction to neuropsychology)

The effects of age, subcortical vascular disease, apolipoprotein E (APOE) epsilon 4 allele and hypertension on entorhinal cortex (ERC) and hippocampal atrophy rates were explored in a longitudinal MRI study with 42 cognitively normal (CN) elderly subjects from 58 to 87 years old. The volumes of the ERC, hippocampus, and white matter hyperintensities (WMH) and the presence of lacunes were assessed on MR images. Age was significantly associated with increased atrophy rates of 0.04 +/- 0.02% per year for ERC and 0.05 +/- 0.02% per year for hippocampus. Atrophy rates of hippocampus, but not that of ERC increased with presence of lacunes, in addition to age. WMH, APOE 84 and hypertension had no significant effect on atrophy rates. In conclusion, age and presence of lacunes should be taken into consideration in imaging studies of CN subjects and AD patients to predict AD progression and assess the response to treatment trials. (c) 2005 Elsevier Inc. All rights reserved.

/pdf/age-effects-on-atrophy-rates-of-entorhinal-cortex-and-3ofop3u3lj.pdf

Age effects on atrophy rates of entorhinal cortex and hippocampus - eScholarship

Photobiomodulation (PBM) therapy, previously known as low-level laser therapy, was discovered more than 50 years ago, yet there is still no agreement on the parameters and protocols for its clinical application. Some groups have recommended the use of a power density less than 100  mW/cm2 and an energy density of 4 to 10  J/cm2 at the level of the target tissue. Others recommend as much as 50  J/cm2 at the tissue surface. The wide range of parameters that can be applied (wavelength, energy, fluence, power, irradiance, pulse mode, treatment duration, and repetition) in some cases has led to contradictory results. In our review, we attempt to evaluate the range of effective and ineffective parameters in PBM. Studies in vitro with cultured cells or in vivo with different tissues were divided into those with higher numbers of mitochondria (muscle, brain, heart, nerve) or lower numbers of mitochondria (skin, tendon, cartilage). Graphs were plotted of energy density against power density. Although the results showed a high degree of variability, cells/tissues with high numbers of mitochondria tended to respond to lower doses of light than those with lower number of mitochondria. Ineffective studies in cells with high mitochondrial activity appeared to be more often due to over-dosing than to under-dosing.

https://www.spiedigitallibrary.org/journals/Journal-of-Biomedical-Optics/volume-23/issue-12/120901/Review-of-light-parameters-and-photobiomodulation-efficacy--dive-into/10.1117/1.JBO.23.12.120901.pdf

Review of light parameters and photobiomodulation efficacy: dive into complexity

It is increasingly acknowledged that creativity involves two phases: a generation phase and an evaluation phase. The two-fold model assumes a cyclic motion between the generation and the evaluation of ideas, as common or deviant ideas are rejected, and novel and appropriate ideas receive further attention and elaboration. Here we synthesize recent neuroimaging findings into an extended two-fold model, and emphasize the important role of the evaluation phase. The model aims to explain how different environmental processes, like expertise and enculturation, affect creativity. We further divide the evaluation phase into three sub stages: valuation, monitoring, and selection. We provide evidence for the model and suggest that creativity research would greatly benefit from incorporating the extended two-fold model into future research questions.

The two-fold model of creativity: the neural underpinnings of the generation and evaluation of creative ideas

Default network contributions to episodic and semantic processing during divergent creative thinking: A representational similarity analysis.

Previous and more recent work of analyzing structural changes in the brain suggest that certain brain regions such as the frontal lobe are among the brain regions profoundly affected by the aging process across males and females. Also, a unified model of structural changes in a normally aging brain is still lacking. The present study investigated age-related structural brain changes in gray matter from young to early middle-age adulthood for males and females. Magnetic resonance images of 215 normal and healthy participants between the ages of 21-45 years were acquired. Changes in gray matter were assessed using voxel-based morphometry and gray matter volumetric analysis. The results showed significant decrease in gray matter volume between the youngest and oldest groups in the following brain regions: frontal, temporal, and parietal lobes. Grey matter loss in the frontal lobe was among the most widespread of all brain regions across the comparison groups that showed significant age-related changes in grey matter for both males and females. This work provides a unique pattern of age-related decline of normal and healthy adult males and females that can aid in the future development of a unified model of normal brain aging.

A voxel-based morphometric magnetic resonance imaging study of the brain detects age-related gray matter volume changes in healthy subjects of 21-45 years old.

Parkinson's disease (PD) is a severe incurable neurological disorder. It is mostly characterized by non-motor symptoms like fatigue, dementia, anxiety, speech and communication problems, depression, and so on. Electroencephalography (EEG) play a key role in the detection of the true emotional state of a person. Various studies have been proposed for the detection of emotional impairment in PD using filtering, Fourier transforms, wavelet transforms, and non-linear methods. However, these methods require a selection of basis and are confined in terms of accuracy. In this paper, tunable Q wavelet transform (TQWT) is proposed for the classification of emotions in PD and normal controls (NC). EEG signals of six emotional states namely happiness, sadness, fear, anger, surprise, and disgust are studied. Power, entropy, and statistical moments based features are elicited from the highpass and lowpass sub-bands of TQWT. Six features selected by statistical analysis are classified with a k-nearest neighbor, probabilistic neural network, random forest, decision tree, and extreme learning machine. Three performance measures are obtained, maximum mean accuracy, sensitivity, and specificity of 96.16%, 97.59%, and 88.51% for NC and 93.88%, 96.33%, and 81.67% for PD are achieved with a probabilistic neural network. The proposed method proved to be very effective such that it classifies emotions in PD and could be used as a potential tool for diagnosing emotional impairment in hospitals.

/pdf/tunable-q-wavelet-transform-based-emotion-classification-in-1q8fzzoj85.pdf

Tunable Q wavelet transform based emotion classification in Parkinson's disease using Electroencephalography.

Age-related effects were studied in 14 younger (M = 34 years) and 14 (M = 47 years) older healthy participants. Event-related potential (ERP) recording was done using a 256-channel EEG system. Results indicated that ERP is affected by advanced age. There was a significant difference in P200 mean latency between the younger participants and older participants for the target (low-probability) stimuli, but no such significance was evident for the P200 mean latency during the presentation of the standard (high-probability) stimuli. As for the P200 mean peak amplitude, the results for the target (low-probability) stimuli did show a significant difference between the two age groups, while the results for the standard (high-probability) stimuli did not show any significant difference between the two age groups. The results of this study are explained in light of aging effects on attentional recruitment and frontal lobe intactness.

https://www.degruyter.com/downloadpdf/j/tnsci.2018.9.issue-1/tnsci-2018-0011/tnsci-2018-0011.xml

Neurophysiological Effects of Aging: A P200 ERP Study.

Augmenting creative performance has the potential to benefit both the individual and our society. Several studies have evaluated the impact of different behavioral training or induction methods on creativity. However, the findings are mixed and sometimes contradictory. Four different short-term induction methods which differed along two information processing dimensions—modality and demand—were compared within a single experimental paradigm alongside a non-induction control group to determine which was the most effective at improving creativity. A comparison on the experimental inductions revealed that low-demand induction methods boosted creativity more than high-demand induction methods. However, this pattern was not maintained when comparisons included the non-induction control. These findings provide insights on important factors and control variables that need to be taken into account at the level of experimental design in order to be able to evaluate the efficacy of different induction and training methods on creativity.

/pdf/comparing-the-efficacy-of-four-brief-inductions-in-boosting-3v3dy4bdcz.pdf

Comparing the Efficacy of Four Brief Inductions in Boosting Short-Term Creativity

Sex-biased psychophysiology, behavior, brain function, and conditions are extensive, yet underlying structural brain mechanisms remain unclear. There is contradicting evidence regarding sexual dimorphism when it comes to brain structure, and there is still no consensus on whether or not there exists such a dimorphism for brain white matter. Therefore, we conducted a voxel-based morphometry (VBM) analysis along with global volume analysis for white matter across sex. We analyzed 384 T1-weighted MRI brain images (192 male, 192 female) to investigate any differences in white matter (WM) between males and females. In the VBM analysis, we found males to have larger WM, compared to females, in occipital, temporal, insular, parietal, and frontal brain regions. In contrast, females showed only one WM region to be significantly larger than males: the right postcentral gyrus in the parietal lobe region. Although, on average, males showed larger global WM volume, we did not find any significant difference in global WM volume between males and females.

Ali K. Bourisly

Papers

A voxel-based morphometric magnetic resonance imaging study of the brain detects age-related gray matter volume changes in healthy subjects of 21-45 years old.

Tunable Q wavelet transform based emotion classification in Parkinson's disease using Electroencephalography.

Neurophysiological Effects of Aging: A P200 ERP Study.

Comparing the Efficacy of Four Brief Inductions in Boosting Short-Term Creativity

White Matter Sexual Dimorphism of the Adult Human Brain.