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Alicia Tosoni
Researcher at Academy for Urban School Leadership
Publications - 130
Citations - 5875
Alicia Tosoni is an academic researcher from Academy for Urban School Leadership. The author has contributed to research in topics: Temozolomide & Medicine. The author has an hindex of 35, co-authored 115 publications receiving 5295 citations. Previous affiliations of Alicia Tosoni include University of Padua & Vita-Salute San Raffaele University.
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Journal ArticleDOI
MGMT Promoter Methylation Status Can Predict the Incidence and Outcome of Pseudoprogression After Concomitant Radiochemotherapy in Newly Diagnosed Glioblastoma Patients
Alba A. Brandes,Enrico Franceschi,Alicia Tosoni,V. Blatt,Annalisa Pession,Giovanni Tallini,Roberta Bertorelle,Stefania Bartolini,Fabio Calbucci,Alvaro Andreoli,G. Frezza,Marco Leonardi,F. Spagnolli,Mario Ermani +13 more
TL;DR: PsPD has a clinical impact on chemotherapy-treated GBM, as it may express the glioma killing effects of treatment and is significantly correlated with MGMT status.
Journal ArticleDOI
Randomized Phase II Trial of Erlotinib Versus Temozolomide or Carmustine in Recurrent Glioblastoma: EORTC Brain Tumor Group Study 26034
Martin J. van den Bent,Alba A. Brandes,Roy Rampling,Mathilde C.M. Kouwenhoven,Johan M. Kros,Antoine F. Carpentier,Paul Clement,Marc Frenay,Mario Campone,Jean-François Baurain,Jean-Paul Armand,Martin J.B. Taphoorn,Alicia Tosoni,Heidemarie Kletzl,Barbara Klughammer,Denis Lacombe,Thierry Gorlia +16 more
TL;DR: Erlotinib has insufficient single-agent activity in unselected GBM, and the use of enzyme-inducing anticonvulsants significantly increased erlot inib clearance, but pharmacokinetic findings were not related to outcome.
Journal ArticleDOI
Recurrence Pattern After Temozolomide Concomitant With and Adjuvant to Radiotherapy in Newly Diagnosed Patients With Glioblastoma: Correlation With MGMT Promoter Methylation Status
Alba A. Brandes,Alicia Tosoni,Enrico Franceschi,Guido Sotti,G. Frezza,P. Amista,Luca Morandi,F. Spagnolli,Mario Ermani +8 more
TL;DR: After the administration of TMZ concomitant with and adjuvant to RT in patients with GBM, the pattern of, and time to, recurrence are strictly correlated with MGMT methylation status.
Journal ArticleDOI
Disease progression or pseudoprogression after concomitant radiochemotherapy treatment: Pitfalls in neurooncology
Alba A. Brandes,Alicia Tosoni,F. Spagnolli,G. Frezza,Marco Leonardi,Fabio Calbucci,Enrico Franceschi +6 more
TL;DR: The causes of radionecrosis and the potential effect of adjuvant chemotherapy concomitant with radiotherapy on its rate and onset are discussed.
Journal ArticleDOI
Temozolomide 3 weeks on and 1 week off as first-line therapy for recurrent glioblastoma: phase II study from gruppo italiano cooperativo di neuro-oncologia (GICNO).
Alba A. Brandes,Alicia Tosoni,Giovanna Cavallo,Roberta Bertorelle,V Gioia,Enrico Franceschi,M Biscuola,V. Blatt,L. Crinò,Mario Ermani +9 more
TL;DR: The prolonged temozolomide schedule considered in the present study is followed by a high PFS-6 rate; toxicity is acceptable and further randomised trials should be conducted to confirm the efficacy of this regimen.