Alison J. Cox

TL;DR: Assessment of VEGF, 125I-VEGF binding, and vascular endothelial growth factor receptor-2 (VEGFR-2) in the kidney was performed after 3 and 32 weeks of streptozotocin-induced diabetes to indicate an early and persistent increase in renal V EGF gene expression in association with experimental diabetes.

TL;DR: The predominant expression of the (P)RR at the apex of acid-secreting cells in the collecting duct, along with its colocalization and homology with an accessory protein of the vacuolar H+-ATPase, suggests that the ( P)RR may function primarily in distal nephron H+ transport, recently noted to be, at least in part, an angiotensin II–dependent phenomenon.

TL;DR: Modulation in nephrin expression is related to the extent of proteinuria in diabetic nephropathy and the effects of anti-proteinuric treatment with ACE inhibition, at a molecular level alterations in the glomerulus.

TL;DR: An interaction between the intrarenal RAS and TGF-β in the pathogenesis of the glomerular and tubulointerstitial fibrosis that follow a major reduction in renal mass is suggested.

TL;DR: Treatment of diabetic rats with aminoguanidine resulted in significant amelioration of the described pathological changes including overexpression of TGF-beta1 and alpha1 (IV) collagen, which implicate the formation of AGEs in T GF-beta overeexpression and tissue changes which accompany the diabetic state.