Showing papers in "Kidney International in 1997"

TL;DR: A systematic analysis to determine baseline factors that predict the decline in GFR, or which alter the efficacy of the diet or blood pressure interventions, found an approximately linear mean GFR decline as renal disease progresses.

TL;DR: This article reviewed the abundant evidence in the literature that the process of reabsorption of filtered proteins activates the proximal tubular epithelium and gave rise to an inflammatory reaction that in most forms of glomerulonephritis consistently precede renal scarring.

TL;DR: A general model of activation is proposed in which latent TGF-beta is released from the extracellular matrix by proteases, localized to cell surfaces, and activated by cell-associated plasmin.

TL;DR: The expression of the calcium-sensing receptor (CaR) at the gene message and the protein level in parathyroid tissue obtained from patients with I degree non-uremic or II degree uremic hyperparathyroidism was compared with that in normal parathyoid tissue, using in situ hybridization and immunohistochemistry techniques.

TL;DR: This review will first place hyperhomocysteinemia in the context of the other established amino acid abnormalities characteristic of ESRD, followed by discussions of the epidcmiological and experimental evidence linking hyper-

TL;DR: Current hemodynamic concepts of arterial function and its alterations in end-stage renal disease are introduced and its functional alterations have different origins and consequences are introduced.

TL;DR: These TGF-13 effects are shown as the cause of the rapid deposition of matrix in the injured glomeruli in a model of acute glomerulonephritis.

TL;DR: It is shown that, in uremia, CML and pentosidine production is determined both by an increased oxidative stress and the availability of precursors such as oxiAA, which suggests that AGE, that is, C ML andpentosidine, production is accelerated under oxidative stress, even in the absence of glucose.

TL;DR: Renal survival was significantly worse in blacks compared with white patients and the factors that predispose black patients to more aggressive and treatment-resistant lupus nephritis are not apparent.

TL;DR: The selected ion flow tube (SIFT) technique as mentioned in this paper was proposed for the accurate measurement of trace gases, particularly when present in complex mixtures, in which molecules (M) present on the breath are "soft" ionized utilizing a precursor ion, such as H3O, which usually results in a single product, MH, which can then be detected by a mass spectrometer, thus allowing identification and quantification of trace gas with a sensitivity of 10 to 20 ppb from a single breath exhalation.

TL;DR: The results of this study indicate that AGEs become dominantly accumulated in the vascular wall in accordance with the prolongation of CAPD treatment, and this might play some roles for the increased permeability of the peritoneal membrane in CAPD.

TL;DR: Patients with Bartter's and Gitelman's syndromes, diseases of salt transport in the loop and distal tubule, respectively, are associated with disturbances in renal magnesium handling and familial diseases associated with renal magnesium-wasting provide a unique opportunity to study these intrinsic controls.

TL;DR: Increased reactivity of intact or de-sialylated serum IgA1 with N-acetylgalactosamine (GalNAc)-specific lectins, Helix aspersa (HAA) and Caragana arborescens (CAA) indicated that the Gal deficiency is in glycans located in the hinge region of IgA 1 molecules.

TL;DR: Structural analysis of Hif-1 alpha revealed that dimerization with HIF-1 beta (ARNT) requires the HLH and PAS domains, DNA binding is mediated by the basic domain, and that HIF -1 alpha contains a carboxyl-terminal transactivation domain.

TL;DR: Recent findings suggesting that congenital nephron endowment is a significant factor in the pathogenesis of chronic renal disease and hypertension are summarized.

TL;DR: It is indicated that blockade of CD11/CD18 integrins and intercellular adhesion molecule-1 (ICAM-1) attenuates ARF in some experimental models of renal ischemia, which may herald the development of novel anti-adhesion strategies for use in human disease.

TL;DR: Additional studies are required to evaluate the role of leptin in mediating the anorexia of uremia and peripheral leptin levels factored for body mass index was increased by > fourfold as compared to a group of healthy controls.

TL;DR: The results document that the decrease in renal hemodynamics with senescence is less marked than suggested by some studies using less stringent methodology and inclusion criteria and that confounding factors such as hypertension or atherosclerosis confound renal function in the elderly.

TL;DR: It is concluded that early protocol biopsies performed early after transplantation in stable grafts can predict graft failure due to chronic transplant nephropathy and are useful to detect patients at risk of losing their graft.

TL;DR: Access blood flow measured by either Dilution or Doppler is a reliable indicator of subsequent short-term thrombosis risk and will likely become the method of choice for screening of PTFE vascular access dysfunction in hemodialysis patients.

TL;DR: Patients with renal failure had markedly reduced clearance of tHcy from plasma, which probably accounts for their hyperhomocysteinemia.

TL;DR: In this paper, a granulocyte inhibiting protein (GIP) with homology to immunoglobulin light chains has been isolated from peritoneal dialysis patients, and p-cresol was identified as a uremic solute that impairs the respiratory burst activity of polymorphonuclear leukocytes.

TL;DR: The role of intracellular calcium, the calcium-dependent enzymes calpain, phospholipase A2 and nitric oxide synthase (NOS), in the pathophophysiology of this renal tubular cell injury during hypoxia/ischemia is described and potential mechanisms whereby tubular injury leads to a profound fall in GFR, including increased tubuloglomerular feedback and increased distal tubular obstruction, in ischemic acute renal failure are proposed.

TL;DR: The striking inhomogeneity of oxygen supply that characterizes the kidney has important implications for renal pathophysiology and disease.

TL;DR: The African American Study of Kidney Disease (AASK) trial as discussed by the authors was designed to examine the impact of antihypertensive therapies and two levels of blood pressure control on the rate of decline of GFR in African Americans with presumed hypertensive renal disease.

TL;DR: Endothelium dependent dilation of the brachial artery is impaired in children with CRF who do not have co-existing risk factors for atherosclerosis, and this may represent early evidence of atherogenic vascular disease.

TL;DR: Larger molecule elimination was shown important not only for preventing beta 2m amyloidosis, but for prolonging survival of dialysis patients as well.

TL;DR: The analyses suggest that the low-protein and very-low-protein diets used in the MDRD Study are safe for periods of two to three years, but both protein and energy intake declined and there were small but significant declines in various indices of nutritional status.