H
Howard Leong-Poi
Researcher at University of Toronto
Publications - 197
Citations - 8311
Howard Leong-Poi is an academic researcher from University of Toronto. The author has contributed to research in topics: Internal medicine & Heart failure. The author has an hindex of 39, co-authored 180 publications receiving 7333 citations. Previous affiliations of Howard Leong-Poi include University of Virginia & St. Michael's Hospital.
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Journal ArticleDOI
Angiotensin-converting enzyme 2 protects from severe acute lung failure
Yumiko Imai,Keiji Kuba,Shuan Rao,Yi Huan,Feng Guo,Bin Guan,Peng Yang,Renu Sarao,Teiji Wada,Howard Leong-Poi,Michael A. Crackower,Akiyoshi Fukamizu,Chi-chung Hui,Lutz Hein,Stefan Uhlig,Arthur S. Slutsky,Chengyu Jiang,Josef M. Penninger +17 more
TL;DR: It is reported that ACE2 and the angiotensin II type 2 receptor (AT2) protect mice from severe acute lung injury induced by acid aspiration or sepsis, pointing to a possible therapy for a syndrome affecting millions of people worldwide every year.
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Imaging Tumor Angiogenesis With Contrast Ultrasound and Microbubbles Targeted to αvβ3
Dilantha B. Ellegala,Howard Leong-Poi,Joan E. Carpenter,Alexander L. Klibanov,Sanjiv Kaul,Mark E. Shaffrey,Jiri Sklenar,Jonathan R. Lindner +7 more
TL;DR: CEU with microbubbles targeted to &agr;v&bgr;3 can noninvasively detect early tumor angiogenesis and, when coupled with changes in blood volume and velocity, may provide insights into the biology of tumor Angiogenesis.
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Noninvasive Assessment of Angiogenesis by Ultrasound and Microbubbles Targeted to αv-Integrins
Howard Leong-Poi,Jonathan P. Christiansen,Alexander L. Klibanov,Sanjiv Kaul,Jonathan R. Lindner +4 more
TL;DR: CEU with microbubbles targeted for &agr;v-integrins may provide a noninvasive method for assessing therapeutic angiogenesis.
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Clinical Applications of Ultrasonic Enhancing Agents in Echocardiography: 2018 American Society of Echocardiography Guidelines Update.
Thomas R. Porter,Sharon L. Mulvagh,Sahar S. Abdelmoneim,Harald Becher,J. Todd Belcik,Michelle Bierig,Jonathan B. Choy,Nicola Gaibazzi,Linda D. Gillam,Rajesh Janardhanan,Shelby Kutty,Howard Leong-Poi,Jonathan R. Lindner,Michael L. Main,Wilson Mathias,Margaret M. Park,Roxy Senior,Flordeliza S. Villanueva +17 more
TL;DR: The aim of this conference is to provide a platform for the development of a new generation of scientists and clinicians to address the rapidly changing environment in which the authors live and work.
Journal ArticleDOI
The (Pro)Renin Receptor: Site-Specific and Functional Linkage to the Vacuolar H+-ATPase in the Kidney
Andrew Advani,Darren J. Kelly,Alison J. Cox,Kathryn White,Suzanne L. Advani,Kerri Thai,Kim A. Connelly,Darren A. Yuen,Judy Trogadis,Andrew M. Herzenberg,Michael A. Kuliszewski,Howard Leong-Poi,Richard E. Gilbert +12 more
TL;DR: The predominant expression of the (P)RR at the apex of acid-secreting cells in the collecting duct, along with its colocalization and homology with an accessory protein of the vacuolar H+-ATPase, suggests that the ( P)RR may function primarily in distal nephron H+ transport, recently noted to be, at least in part, an angiotensin II–dependent phenomenon.