A
Allan Z. Zhao
Researcher at Guangdong University of Technology
Publications - 78
Citations - 3965
Allan Z. Zhao is an academic researcher from Guangdong University of Technology. The author has contributed to research in topics: Leptin & Cancer. The author has an hindex of 30, co-authored 67 publications receiving 3444 citations. Previous affiliations of Allan Z. Zhao include University of Pittsburgh & University of Washington.
Papers
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Journal ArticleDOI
Rheb/mTORC1 Signaling Promotes Kidney Fibroblast Activation and Fibrosis
Lei Jiang,Lingling Xu,Junhua Mao,Jianzhong Li,Li Fang,Yang Zhou,Wei Liu,Weichun He,Allan Z. Zhao,Junwei Yang,Chunsun Dai +10 more
TL;DR: It is found that Rheb/mTORC1 signaling was activated in interstitial myofibroblasts from fibrotic kidneys and contributes to the development of interstitial fibrosis, possibly providing a therapeutic target for progressive renal disease.
Journal ArticleDOI
Regulation of adiponectin and leptin secretion and expression by insulin through a PI3K-PDE3B dependent mechanism in rat primary adipocytes.
TL;DR: It is concluded that insulin and beta-agonists act directly at the adipocytes in opposing fashions to regulate the production of adiponectin and leptin, and that a PI3K-PDE3B-cAMP pathway mediates the effects of insulin to restore beta-agonist/cAMP-suppressed secretion and expression of these two adipokines.
Book ChapterDOI
Cyclic Nucleotide Phosphodiesterases: Gene Complexity, Regulation by Phosphorylation, and Physiological Implications
TL;DR: This chapter reports regulation of cellular PDE activity via phosphorylation–dephosphorylation reactions and speculation on the physiological significance that phosphorylated may play in the modulation of cyclic nucleotide levels and on the possible effect of this mode of regulation on cellular function.
Journal ArticleDOI
Annexin II stimulates RANKL expression through MAPK.
Li Fanghong,Ho Yeon Chung,Sakamuri V. Reddy,Ganwei Lu,Noriyoshi Kurihara,Allan Z. Zhao,G. David Roodman +6 more
TL;DR: It is reported that AX‐II, in addition to inducing GM‐CSF expression, also increases membrane‐bound RANKL synthesis by marrow stromal cells and does so through a previously unreported MAPK‐dependent pathway.
Journal ArticleDOI
Endogenous ω-3 Polyunsaturated Fatty Acid Production Confers Resistance to Obesity, Dyslipidemia, and Diabetes in Mice
Jie Li,Fanghong R. Li,Dong Wei,Wei Jia,Jing X. Kang,Maja Stefanovic-Racic,Yifan Dai,Allan Z. Zhao +7 more
TL;DR: Exogenous conversion of ω-6 to ψ-3 PUFAs via fat-1 strongly protects against obesity, diabetes, inflammation, and dyslipidemia and may represent a novel therapeutic modality to treat these prevalent disorders.