A
Allan Z. Zhao
Researcher at Guangdong University of Technology
Publications - 78
Citations - 3965
Allan Z. Zhao is an academic researcher from Guangdong University of Technology. The author has contributed to research in topics: Leptin & Cancer. The author has an hindex of 30, co-authored 67 publications receiving 3444 citations. Previous affiliations of Allan Z. Zhao include University of Pittsburgh & University of Washington.
Papers
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Journal ArticleDOI
Functional Role of Phosphodiesterase 3 in Cardiomyocyte Apoptosis Implication in Heart Failure
Bo Ding,Jun Ichi Abe,Heng Wei,Qunhua Huang,Richard A. Walsh,Carlos A. Molina,Allan Z. Zhao,Junichi Sadoshima,Burns C. Blaxall,Bradford C. Berk,Chen Yan +10 more
TL;DR: It is suggested that PDE3A reduction and consequent inducible cAMP early repressor induction are critical events in Ang II– and isoproterenol-induced cardiomyocyte apoptosis and may contribute to the development of heart failure.
Journal ArticleDOI
Phosphorylation and inhibition of olfactory adenylyl cyclase by CaM kinase II in Neurons: a mechanism for attenuation of olfactory signals.
Jia Wei,Allan Z. Zhao,Guy C.-K. Chan,Lauren P. Baker,Soren Impey,Joseph A. Beavo,Daniel R. Storm +6 more
TL;DR: A polyclonal antibody specific for AC3 phosphorylation was generated and blocked by inhibitors of CaMKII, which also ablated cAMP decreases associated with odorant-stimulated cAMP transients, defining a novel mechanism for termination of olfactory signaling that may be important in olfaction responses.
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Molecular cloning and characterization of a calmodulin-dependent phosphodiesterase enriched in olfactory sensory neurons
TL;DR: The molecular cloning, expression, and characterization of a cDNA from rat olfactory epithelium that encodes a member of the calmodulin-dependent PDE family designated as PDE1C is reported, showing high affinity for cAMP and cGMP, which suggests an important role for it in a Ca(2+)-regulated Olfactory signal termination.
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The Calmodulin-dependent Phosphodiesterase Gene PDE1C Encodes Several Functionally Different Splice Variants in a Tissue-specific Manner
TL;DR: Findings suggest that the PDE1C gene undergoes tissue-specific alternative splicing that generates structurally and functionally diverse gene products that are differentially regulated in a tissue/cell-specific manner.
Journal ArticleDOI
Attenuation of insulin secretion by insulin-like growth factor 1 is mediated through activation of phosphodiesterase 3B
TL;DR: A new regulatory feedback loop model for the control of insulin secretion is suggested, in this model, increased insulin secretion in vivo will stimulate IGF-1 synthesis by the liver, and the secreted IGF- 1 in turn feedback inhibits insulin secretion from the beta cells through an IGF-2 receptor-mediated pathway.