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Allan Z. Zhao
Researcher at Guangdong University of Technology
Publications - 78
Citations - 3965
Allan Z. Zhao is an academic researcher from Guangdong University of Technology. The author has contributed to research in topics: Leptin & Cancer. The author has an hindex of 30, co-authored 67 publications receiving 3444 citations. Previous affiliations of Allan Z. Zhao include University of Pittsburgh & University of Washington.
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Perfluorooctanoic acid exposure alters polyunsaturated fatty acid composition, induces oxidative stress and activates the AKT/AMPK pathway in mouse epididymis.
TL;DR: Altered polyunsaturated fatty acid (PUFA) compositions, such as a higher arachidonic acid:linoleic acid (AA:LA) ratio, concomitant with excessive oxidative stress, and Oxidative stress and PUFA alteration might help explain the sperm injury and male reproductive dysfunction induced by PFOA exposure.
Journal Article
Recent advances in the study of Ca2+/CaM-activated phosphodiesterases: expression and physiological functions.
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Oxidized-LDL inhibits testosterone biosynthesis by affecting mitochondrial function and the p38 MAPK/COX-2 signaling pathway in Leydig cells.
Jun Jing,Jun Jing,Ning Ding,Dan-Dan Wang,Dan-Dan Wang,Xie Ge,Xie Ge,Jinzhao Ma,Jinzhao Ma,Rujun Ma,Rujun Ma,Xuan Huang,Xuan Huang,Kadiliya Jueraitetibaike,Kadiliya Jueraitetibaike,Kuan Liang,Kuan Liang,Shuxian Wang,Shuxian Wang,Siyuan Cao,Siyuan Cao,Allan Z. Zhao,Bing Yao,Bing Yao +23 more
TL;DR: This study first showed the specific localization of oxLDL and mitochondrial structural damage in testicular Leydig cells of high-fat diet-fed mice in vivo and provided the first evidence that ox LDL is a novel metabolic biomarker of male-acquired hypogonadism caused by abnormal lipid metabolism.
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Fibroblast mTOR/PPARγ/HGF axis protects against tubular cell death and acute kidney injury.
Yuan Gui,Qingmiao Lu,Mengru Gu,Mingjie Wang,Yan Liang,Xingwen Zhu,Xian Xue,Xiaoli Sun,Weichun He,Junwei Yang,Allan Z. Zhao,Bo Xiao,Chunsun Dai +12 more
TL;DR: The data suggest that mTOR signaling activation in kidney fibroblasts protects against tubular cell death and dictates the outcome of AKI through stimulating PPARγ and HGF expression.
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Elevation of ω-3 Polyunsaturated Fatty Acids Attenuates PTEN-deficiency Induced Endometrial Cancer Development through Regulation of COX-2 and PGE2 Production
Jinshun Pan,Lixian Cheng,Xinyun Bi,Xin Zhang,Shanshan Liu,Xiaoming Bai,Li Fanghong,Allan Z. Zhao +7 more
TL;DR: The direct inhibitory effects of ω-3 PUFAs on endometrial cancer development and the underlying mechanisms involving reduction of COX-2 and PGE2 are revealed.