A
Alphonse Le Cam
Researcher at Centre national de la recherche scientifique
Publications - 4
Citations - 278
Alphonse Le Cam is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: Promoter & Gene expression. The author has an hindex of 3, co-authored 4 publications receiving 265 citations.
Papers
More filters
Journal ArticleDOI
Negative regulation of transcription by the type II arginine methyltransferase PRMT5.
Eric Fabbrizio,Selma El Messaoudi,Jolanta Polanowska,Conception Paul,Jeffry R. Cook,Jin-Hyung Lee,Vincent Negre,M. Rousset,Sidney Pestka,Alphonse Le Cam,Claude Sardet +10 more
TL;DR: Ch Chromatin immunoprecipitations show that PRMT5 is associated specifically with the transcription start site region of the cyclin E1 promoter, providing the first direct experimental evidence that a type II arginine methylase is involved in the control of transcription and proliferation.
Journal ArticleDOI
Electroporation-mediated gene transfer into hepatocytes: Preservation of a growth hormone response
TL;DR: An electroporation procedure is described which allows the introduction of foreign genes into freshly isolated rat hepatocytes while preserving their growth hormone responsiveness, and was successfully applied to the study of a growth hormone-dependent serine protease inhibitor gene promoter.
cis-Acting Elements Controlling Transcription from Rat Serine Protease Inhibitor 2.1 Gene Promoter
Alphonse Le Cam,Vbronique Pantescu,Laurent Paquereau,Catherine Legraverend,GBrard Fauconnier,Guillermina Asins +5 more
TL;DR: Results have revealed the existence of an apparently new type of promoter functioning that strictly depends on the integrity of a key regulatory (G + A) motif.
Journal ArticleDOI
Expression of the pp63 gene encoding the insulin receptor tyrosine kinase inhibitor in proliferating liver and in liver tumors.
TL;DR: After partial hepatectomy in rats, a approximately 4-fold decrease in pp63 mRNA level was detected at 24 h, but not at earlier time points, while in mice, during liver cell proliferation induced by 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene and phenobarbital, pp63 transcript levels had a decrease of 40-50%.