A
Alvaro J. Romanha
Researcher at Oswaldo Cruz Foundation
Publications - 180
Citations - 7491
Alvaro J. Romanha is an academic researcher from Oswaldo Cruz Foundation. The author has contributed to research in topics: Trypanosoma cruzi & Benznidazole. The author has an hindex of 47, co-authored 180 publications receiving 6983 citations. Previous affiliations of Alvaro J. Romanha include Universidade Federal de Juiz de Fora & Universidade Federal de Santa Catarina.
Papers
More filters
Journal ArticleDOI
[Use of random amplified polymorphic DNA (RAPD) in the populational study of Triatoma brasiliensis Neiva, 1911].
TL;DR: In this paper, the authors evaluated the genetic variability of Triatoma brasiliensis, the main vector of Chagas disease in Northeast Brazil, using specimens from three populations.
Journal ArticleDOI
Drug transporter and oxidative stress gene expression in human macrophages infected with benznidazole-sensitive and naturally benznidazole-resistant Trypanosoma cruzi parasites treated with benznidazole.
TL;DR: Findings suggest that the proteins encoded by AQP1, AQP9 and ABCB1 may be implicated in benznidazole detoxification in Chagas disease.
Journal ArticleDOI
Endothelin-1 receptors play a minor role in the protection against acute Trypanosoma cruzi infection in mice
Ester Roffê,Adriano L.S. Souza,P.P. Machado,Lucíola S. Barcelos,Alvaro J. Romanha,Flávia S. Mariano,João Santana da Silva,Conceição R. S. Machado,Herbert B. Tanowitz,Mauro M. Teixeira +9 more
TL;DR: The data suggest that bosentan-treated mice have a delay in controlling parasitism which is compensated for exacerbated inflammation, demonstrating that ET-1 plays a minor role in the protection against acute murine T. cruzi infection.
Journal ArticleDOI
Constituents from stem barks of Luehea ochrophylla Mart and evaluation of their antiparasitic, antimicrobial, and antioxidant activities
Clináscia Rodrigues Rocha Araújo,Roqueline R. Silva,Thiago M. Silva,Jacqueline A. Takahashi,P A Sales-Junior,N A V Dessimoni-Pinto,Elaine M. Souza-Fagundes,Alvaro J. Romanha,Silvane M. F. Murta,Antônio F. C. Alcântara +9 more
TL;DR: The structural identification of the isolated compounds was mainly performed by NMR analyses and comparison with the data from literature, and these compounds were isolated for the first time in the genus Luehea, except β-sitosterol glucopyranoside and (−)-epicatechin.
Journal ArticleDOI
Knockdown of Host Antioxidant Defense Genes Enhances the Effect of Glucantime on Intracellular Leishmania braziliensis in Human Macrophages.
TL;DR: The results suggest that human MDMs infected with L. braziliensis and treated with SbV express increased levels of genes participating in antioxidant defense, whereas the functional analyses provide evidence for the involvement of humanMDMs in drug detoxification.