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Alvaro J. Romanha

Researcher at Oswaldo Cruz Foundation

Publications -  180
Citations -  7491

Alvaro J. Romanha is an academic researcher from Oswaldo Cruz Foundation. The author has contributed to research in topics: Trypanosoma cruzi & Benznidazole. The author has an hindex of 47, co-authored 180 publications receiving 6983 citations. Previous affiliations of Alvaro J. Romanha include Universidade Federal de Juiz de Fora & Universidade Federal de Santa Catarina.

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Molecular characterization of cytosolic and mitochondrial tryparedoxin peroxidase in Trypanosoma cruzi populations susceptible and resistant to benznidazole

TL;DR: Increased expression of the cytosolic and mitochondrial TcTXNPx in the T. cruzi population with in-vitro-induced resistance to benznidazole is demonstrated.
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New evidence of spontaneous cure in human Chagas' disease

TL;DR: Clinical data suggest the possibility of a benign evolution of Chagas' disease in this case, but the basic findings (slight cardiac and esophageal impairment) could also be due to the advanced age of the patient.
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Isolamento de amostras do Trypanosoma cruzi por xenodiagnóstico e hemocultura de pacientes na fase crônica da doença de Chagas

TL;DR: It was discussed the parasitological comprovation difficulties in chronic chagasic patients, the value of the simultaneous utilization of different triatomine species in xenodiagnosis and the hemoculture, in a favorable positive association to the sensistivity increase in the diagnosis' disease.
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Comparison of polymerase chain reaction with other laboratory methods for the diagnosis of American cutaneous leishmaniasis: diagnosis of cutaneous leishmaniasis by polymerase chain reaction.

TL;DR: The value of PCR is confirmed as an alternative laboratory method for diagnosing ACL, especially for those patients with negative PE and MST, and in the group of patients suspected to have ACL, PCR presented the same positivity as PE andMST together.
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The in vitro leishmanicidal activity of hexadecylphosphocholine (miltefosine) against four medically relevant Leishmania species of Brazil

TL;DR: The in vitro leishmanicidal activity of miltefosine® (Zentaris GmbH) was assessed against four medically relevant Leishmania species of Brazil, suggesting that future clinical trials with this drug should include a laboratory pre-evaluation and a dose-defining step.