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Alvaro J. Romanha
Researcher at Oswaldo Cruz Foundation
Publications - 180
Citations - 7491
Alvaro J. Romanha is an academic researcher from Oswaldo Cruz Foundation. The author has contributed to research in topics: Trypanosoma cruzi & Benznidazole. The author has an hindex of 47, co-authored 180 publications receiving 6983 citations. Previous affiliations of Alvaro J. Romanha include Universidade Federal de Juiz de Fora & Universidade Federal de Santa Catarina.
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Journal ArticleDOI
Molecular characterization of cytosolic and mitochondrial tryparedoxin peroxidase in Trypanosoma cruzi populations susceptible and resistant to benznidazole
Fernanda de Bruycker Nogueira,Jeronimo C. Ruiz,Carlos Robello,Alvaro J. Romanha,Silvane M. F. Murta +4 more
TL;DR: Increased expression of the cytosolic and mitochondrial TcTXNPx in the T. cruzi population with in-vitro-induced resistance to benznidazole is demonstrated.
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New evidence of spontaneous cure in human Chagas' disease
Sonia S. Francolino,Antonio Fernandez Antunes,Rodolfo Talice,Rachel Rosa,Joel Selanikio,Joffre Marcondes de Rezende,Alvaro J. Romanha,João Carlos Pinto Dias +7 more
TL;DR: Clinical data suggest the possibility of a benign evolution of Chagas' disease in this case, but the basic findings (slight cardiac and esophageal impairment) could also be due to the advanced age of the patient.
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Isolamento de amostras do Trypanosoma cruzi por xenodiagnóstico e hemocultura de pacientes na fase crônica da doença de Chagas
Elisabeth Bronfen,Francisco Silvério de Assis Rocha,Gisele Brandão Nogueira Machado,Maria Marcia Perillo,Alvaro J. Romanha,Egler Chiari +5 more
TL;DR: It was discussed the parasitological comprovation difficulties in chronic chagasic patients, the value of the simultaneous utilization of different triatomine species in xenodiagnosis and the hemoculture, in a favorable positive association to the sensistivity increase in the diagnosis' disease.
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Comparison of polymerase chain reaction with other laboratory methods for the diagnosis of American cutaneous leishmaniasis: diagnosis of cutaneous leishmaniasis by polymerase chain reaction.
Marcos José Marques,Ângela C. Volpini,George Luiz Lins Machado-Coelho,Jackson Machado-Pinto,Carlos Alberto da Costa,Wilson Mayrink,Odair Genaro,Alvaro J. Romanha +7 more
TL;DR: The value of PCR is confirmed as an alternative laboratory method for diagnosing ACL, especially for those patients with negative PE and MST, and in the group of patients suspected to have ACL, PCR presented the same positivity as PE andMST together.
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The in vitro leishmanicidal activity of hexadecylphosphocholine (miltefosine) against four medically relevant Leishmania species of Brazil
Eliane de Morais-Teixeira,Quesia Souza Damasceno,Mariana Kolos Galuppo,Alvaro J. Romanha,Ana Rabello +4 more
TL;DR: The in vitro leishmanicidal activity of miltefosine® (Zentaris GmbH) was assessed against four medically relevant Leishmania species of Brazil, suggesting that future clinical trials with this drug should include a laboratory pre-evaluation and a dose-defining step.