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Alvaro J. Romanha
Researcher at Oswaldo Cruz Foundation
Publications - 180
Citations - 7491
Alvaro J. Romanha is an academic researcher from Oswaldo Cruz Foundation. The author has contributed to research in topics: Trypanosoma cruzi & Benznidazole. The author has an hindex of 47, co-authored 180 publications receiving 6983 citations. Previous affiliations of Alvaro J. Romanha include Universidade Federal de Juiz de Fora & Universidade Federal de Santa Catarina.
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Journal ArticleDOI
Interleukin-12 Enhances In Vivo Parasiticidal Effect of Benznidazole during Acute Experimental Infection with a Naturally Drug-Resistant Strain of Trypanosoma cruzi
Vladimir Michailowsky,Silvane M. F. Murta,Silvane M. F. Murta,Leonardo Carvalho-Oliveira,Maria Elizabeth S Pereira,Ludmila Rodrigues Pinto Ferreira,Zigman Brener,Alvaro J. Romanha,Ricardo T. Gazzinelli +8 more
TL;DR: The results suggest that early activation of the cellular compartment of the immune system by IL-12 may favor in vivo Bz activity against T. cruzi, and indicate that a higher percentage of mice treated with Bz combined with rIL-12 than mice treatedwith Bz alone are cured.
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Anti-plasmodial and anti-trypanosomal activity of synthetic naphtho[2,3-b]thiophen-4,9-quinones
Carlos L. Zani,Egler Chiari,Antoniana U. Krettli,Silvane M. F. Murta,Mark Cunningham,Alan H. Fairlamb,Alvaro J. Romanha +6 more
TL;DR: The parent compound, naphtho[2,3-b]thiophen-4,9-quinone, was among the most active quinone tested in vitro against P. falciparum but exhibited weak activity at 4 degrees C against trypomastigotes in murine blood as well against the enzyme trypanothione reducatase.
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Synthesis and structure–activity relationship study of a new series of antiparasitic aryloxyl thiosemicarbazones inhibiting Trypanosoma cruzi cruzain
José Wanderlan Pontes Espíndola,Marcos Veríssimo de Oliveira Cardoso,Gevanio Bezerra de Oliveira Filho,Dayane Albuquerque Oliveira e Silva,Diogo Rodrigo Magalhães Moreira,Tanira Matutino Bastos,Carlos A. de Simone,Milena Botelho Pereira Soares,Filipe Silva Villela,Rafaela Salgado Ferreira,Maria Carolina Accioly Brelaz de Castro,Valéria Rêgo Alves Pereira,Silvane M. F. Murta,Policarpo Ademar Sales Junior,Alvaro J. Romanha,Ana Cristina Lima Leite +15 more
TL;DR: This study indicated that apolar substituents or halogen atom substitution at the aryl position improved cruzain inhibition and antiparasitic activity in comparison to unsubstituted thiosemicarbazone.
Leishmaniose tegumentar na Região Metropolitana de Belo Horizonte: aspectos clínicos, laboratoriais, terapêuticos e evolutivos (1989-1995) Cutaneous leishmaniasis in the Metropolitan Region of Belo Horizonte: clinical, laboratorial, therapeutic and prospective aspects
Valéria Maria de Azeredo Passos,Sandhi Maria Barreto,Alvaro J. Romanha,Antoniana U. Krettli,Ângela C. Volpini,Alda Lima Falcão,Maria Fernanda,F. Lima-Costa +7 more
TL;DR: In this paper, the authors investigated clinical, laboratorial, therapeutic and prognostic aspects of American cutaneous leishmaniasis in Belo Horizonte in 358 patients with leishmanniasis and 25 with mucocutaneous leischmaniasis (MCL).
Journal ArticleDOI
Populational structure of Schistosoma mansoni assessed by DNA microsatellites.
N. B. Rodrigues,P. Coura Filho,C. P. de Souza,L. K. Jannoti Passos,Emmanuel Dias-Neto,Alvaro J. Romanha +5 more
TL;DR: The results showed the usefulness of microsatellites for population analysis of S. mansoni, offering a new alternative for a better understanding of schistosomiasis epidemiology.