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Alyson A. Miller
Researcher at RMIT University
Publications - 65
Citations - 3807
Alyson A. Miller is an academic researcher from RMIT University. The author has contributed to research in topics: Cerebral arteries & NADPH oxidase. The author has an hindex of 33, co-authored 65 publications receiving 3348 citations. Previous affiliations of Alyson A. Miller include University of Melbourne & Monash University.
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Obesity and neuroinflammation: a pathway to cognitive impairment.
TL;DR: The evidence that obesity and high fat feeding can lead to cognitive dysfunction is addressed and the idea that obesity-associated systemic inflammation leads to inflammation within the brain, particularly the hypothalamus, and that this is partially responsible for negative cognitive outcomes is examined.
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Direct evidence of a role for Nox2 in superoxide production, reduced nitric oxide bioavailability, and early atherosclerotic plaque formation in ApoE-/- mice.
Courtney P Judkins,Henry Diep,Bradley Randal Scott Broughton,Anja E Mast,Elizabeth U Hooker,Alyson A. Miller,Stavros Selemidis,Gregory J. Dusting,Christopher G. Sobey,Grant R Drummond +9 more
TL;DR: This is the first demonstration of a role for Nox2-NADPH oxidase in vascular ROS production, reduced NO bioavailability, and early lesion development in ApoE(-/-) mice, highlighting this Nox isoform as a potential target for future therapies for atherosclerosis.
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NADPH Oxidase Activity and Function Are Profoundly Greater in Cerebral Versus Systemic Arteries
TL;DR: In cerebral arteries, endogenous H2O2 derived from NAD PH oxidase activation appears to cause relaxation and is able to offset angiotensin II-induced constriction, consistent with the concept that NADPH oxidase-derived reactive oxygen species modulate cerebral vascular tone under physiological conditions.
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Oxidative stress and endothelial dysfunction in cerebrovascular disease
Sophocles Chrissobolis,Alyson A. Miller,Grant R Drummond,Barbara K Kemp-Harper,Christopher G. Sobey +4 more
TL;DR: This review will summarize disease models in which both oxidative stress and endothelial dysfunction occur in the cerebral circulation, namely hypertension involving angiotensin II (Ang II), diabetes, subarachnoid hemorrhage, stroke and Alzheimer's disease.
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Effect of gender on NADPH-oxidase activity, expression, and function in the cerebral circulation: role of estrogen.
TL;DR: NADPH-oxidase activity and function are lower in cerebral arteries of female rats and are associated with lower Nox1 and Nox4 expression.