S
Stavros Selemidis
Researcher at RMIT University
Publications - 91
Citations - 4327
Stavros Selemidis is an academic researcher from RMIT University. The author has contributed to research in topics: NADPH oxidase & Inflammation. The author has an hindex of 29, co-authored 71 publications receiving 3563 citations. Previous affiliations of Stavros Selemidis include Monash University, Clayton campus & Monash University.
Papers
More filters
Journal ArticleDOI
Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets
TL;DR: The concept that compared to the use of conventional antioxidants, inhibiting NOX1 and NOX2 oxidases is a superior approach for combating oxidative stress is advanced.
Journal ArticleDOI
Direct evidence of a role for Nox2 in superoxide production, reduced nitric oxide bioavailability, and early atherosclerotic plaque formation in ApoE-/- mice.
Courtney P Judkins,Henry Diep,Bradley Randal Scott Broughton,Anja E Mast,Elizabeth U Hooker,Alyson A. Miller,Stavros Selemidis,Gregory J. Dusting,Christopher G. Sobey,Grant R Drummond +9 more
TL;DR: This is the first demonstration of a role for Nox2-NADPH oxidase in vascular ROS production, reduced NO bioavailability, and early lesion development in ApoE(-/-) mice, highlighting this Nox isoform as a potential target for future therapies for atherosclerosis.
Journal ArticleDOI
NADPH oxidases in the vasculature: molecular features, roles in disease and pharmacological inhibition.
Stavros Selemidis,Christopher G. Sobey,Kirstin Wingler,Harald H.H.W. Schmidt,Harald H.H.W. Schmidt,Grant R Drummond +5 more
TL;DR: The structural and biochemical characteristics of the NADPH oxidase family are highlighted and the literature on the currently available pharmacological inhibitors of these enzymes are reviewed with a particular emphasis on their mechanisms of action, isoform selectivity and therapeutic potential in cardiovascular disease.
Journal ArticleDOI
Inhibition of Nox2 Oxidase Activity Ameliorates Influenza A Virus-Induced Lung Inflammation
Ross Vlahos,John Stambas,Steven Bozinovski,Bradley Rs Broughton,Grant R Drummond,Stavros Selemidis +5 more
TL;DR: In vivo administration of the Nox2 inhibitor apocynin significantly suppressed viral titer, airways inflammation and inflammatory cell superoxide production following infection with X-31 or PR8 in an influenza strain-independent manner.
Journal ArticleDOI
Analysis of dihydroethidium fluorescence for the detection of intracellular and extracellular superoxide produced by NADPH oxidase
TL;DR: DHE-derived fluorescence at 570 nm is a convenient method for detection of intracellular and extracellular superoxide produced by phagocytic and vascular NADPH oxidase.