Protective effects of boron on cyclophosphamide induced lipid peroxidation and genotoxicity in rats

Protective effect of polydatin, a natural precursor of resveratrol, against cisplatin-induced toxicity in rats.

Damage caused by oxidative stress is involved in many types of diseases, including breast cancer. Our aim was to detect the oxidative stress parameters and blood plasma changes with differential scanning calorimetry (DSC) in breast cancer patients. The study included 40 adult breast cancer women who were grouped according to tumor diameter, regional lymph node metastases, proliferative activity, receptor status and postoperative chemotherapy. To monitor oxidative stress, malondialdehyde, oxygen free radicals (OFRs), activity of myeloperoxidase (MPO), superoxide dismutase (SOD) and catalase (CAT) were measured. Denaturation of plasma components was detected in Setaram Micro DSC-II calorimeter. The total production of OFRs, the MPO activity and lipidperoxidation were significantly increased in each breast cancer patients considering the tumor size, the metastatic lymph nodes, the proliferation activity and receptor status compared with healthy controls (p < 0.05). These pro-oxidants were slightly elevated without chemotherapy, but their values were increased significantly in chemotherapy-receiving group. The activity of SOD and CAT was significantly decreased in all groups, and in regard to the chemotherapy, they were changed significantly parallel to the severity of disease. Regarding to both the increased tumor diameter and the increased number of affected lymph nodes, DSC measurements showed a strong relationship between the maximum excess heat capacity (C
 pmax) of the blood plasma and the severity of disease. The study demonstrated that oxidative stress is implicated in breast carcinoma and chemotherapy aggravates these changes which confirmed the plasma DSC measurements also.

Influence of oxidative injury and monitoring of blood plasma by DSC on breast cancer patients

Oral administration of tea saponins to relive oxidative stress and immune suppression in chickens.

Circulating oxidative stress parameters in pre- and post-menopausal healthy women and in women suffering from breast cancer treated or not with neoadjuvant chemotherapy

Background: Breast cancer is the most common cancer in Indian women.
The aim of this study was to assess the levels of red blood cell (RBC)
superoxide dismutase (r-SOD), RBC catalase (r-CAT), RBC glutathione
peroxidase (r-GPx) and the ferric reducing ability of plasma (FRAP) in
advanced breast cancer patients post mastectomy before and after
chemotherapy. Methods: Female breast cancer patients between 27 and 65
years of age who were admitted to the Department of Surgery of the All
India Institute of Medical Sciences in New Delhi were enrolled in the
study. This study included two arms: a control group of healthy
age-matched females (n = 20) and patients undergoing treatment with a
combination of the anticancer drugs cyclophosphamide, doxorubicin, and
5-fluorouracil (CAF) (n = 55), No treatment was given to the control
group. The CAF group received CAF treatment at weeks 0, 3, and 6, then
surgery at week 9 followed by CAF treatment at weeks 12, 15, and 18. A
three-week drug-free interval was included between each cycle of drug
treatment. Blood samples were collected from control subjects and from
patients in the CAF group before administration of drugs at week zero
to establish a baseline, again weeks 12 and 18, and once more at the
end of the 26-week treatment. Blood samples collected from the control
subjects and CAF patients were analysed to determine levels of the
endogenous antioxidants, r-SOD, r-CAT, r-GPx, and FRAP. Results: Levels
of r-SOD, r-CAT, r-GPx, and FRAP in CAF-treated patients at 12, 18, and
26 weeks were significantly decreased (P < 0.001) in comparison to
the baseline levels observed at week zero. Conclusion: The results from
the present study show that a change in the enzyme antioxidant systems
in patients after chemotherapy and mastectomy causes an overall
decrease in antioxidant levels. Chemotherapeutic agents induce
oxidative stress that damages many cellular targets.

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Amardeep Jaiswal

Papers

Effect on Antioxidant Levels in Patients of Breast Carcinoma during Neoadjuvant Chemotherapy and Mastectomy.