Amarnath Sharma

TL;DR: CP-751,871 has a favorable safety profile and was well tolerated when given in continuous cycles, and at the maximal feasible dose of 20 mg/kg, there was a moderate accumulation in plasma exposure, and most of the treated patients experienced stability of disease.

TL;DR: Data indicate that CP-751,871 is well tolerated and may constitute a novel agent in the treatment of multiple myeloma.

TL;DR: The distribution of the SNP C3435T in exon 26 in the Chinese and Malay population was found to be similar to the Caucasians whereas the Indians were different, and the Asian population differed significantly from the African and Caucasian population in the distribution of this SNP.

TL;DR: The single-dose regimen provided total azithromycin exposures in serum and WBC similar to those of the 3-day regimen, as evidenced by the similar AUC0-120 and trough azithrolycin concentrations in serum or WBC (mononuclear leukocytes [MNL].

TL;DR: It is interesting that one subject in each study exhibited the opposite effect of ritonavir on voriconazole exposure, probably due to lack of CYP2C19, and coadministration with 100 mg BID ritonvir should be avoided, unless an assessment of the benefit/risk to the patient justifies the use.