Amaya Sanz-Rodriguez

TL;DR: The data suggest that miRNAs are important regulators of seizure-induced neuronal death, and in tolerant animals, expression responses of >40% of the injury-group-detected mi RNAs differed, being either unchanged relative to control or down-regulated, and this included miR-132.

TL;DR: It is reported that SE induced by intra‐amygdala kainic acid in mice selectively increased hippocampal levels of P2X7 receptors relative to other P2 X receptors, suggesting that P2x7 receptor antagonists may be a promising class of drug for seizure abrogation and neuroprotection in SE.

TL;DR: The present study was designed to characterize P2X7R in the neocortex and assess effects of P2x7R antagonists on cortical injury after status epilepticus.

TL;DR: Targeting the receptor with a new centrally available antagonist, JNJ-47965567, suppressed epileptic seizures well beyond the time of treatment and reduced underlying gliosis in the hippocampus, suggesting a potential disease-modifying treatment for epilepsy based on targeting the P2X7 receptor.

TL;DR: A role for post-transcriptional regulation of the P2X7R is supported and therapeutic targeting of microRNA-22 may prevent inflammation and development of a secondary epileptogenic focus in the brain is suggested.