D
Detlev Boison
Researcher at Rutgers University
Publications - 168
Citations - 9539
Detlev Boison is an academic researcher from Rutgers University. The author has contributed to research in topics: Adenosine & Adenosine kinase. The author has an hindex of 56, co-authored 151 publications receiving 8056 citations. Previous affiliations of Detlev Boison include Oregon Health & Science University & Washington State University Vancouver.
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Journal ArticleDOI
Adenosine signaling and function in glial cells.
TL;DR: This review will summarize how glial cells contribute to adenosine homeostasis and how glials interact with neurons and the vasculature, and outline new methods to study glial function.
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Arousal Effect of Caffeine Depends on Adenosine A2A Receptors in the Shell of the Nucleus Accumbens
Michael Lazarus,Hai Ying Shen,Yoan Cherasse,Wei-Min Qu,Zhi-Li Huang,Zhi-Li Huang,Caroline E. Bass,Raphaelle Winsky-Sommerer,Kazue Semba,Bertil B. Fredholm,Detlev Boison,Osamu Hayaishi,Yoshihiro Urade,Jiang-Fan Chen +13 more
TL;DR: It is reported that the A2ARs in the shell region of the nucleus accumbens (NAc) are responsible for the effect of caffeine on wakefulness and that caffeine promotes arousal by activating pathways that traditionally have been associated with motivational and motor responses in the brain.
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A ketogenic diet suppresses seizures in mice through adenosine A1 receptors
Susan A. Masino,Tianfu Li,Panos Theofilas,Ursula S. Sandau,David N. Ruskin,Bertil B. Fredholm,Jonathan D. Geiger,Eleonora Aronica,Detlev Boison +8 more
TL;DR: It is shown that ketogenic diet can reduce seizures in mice by increasing activation of adenosine A1 receptors (A1Rs) and that adenosines deficiency may be relevant to human epilepsy and that KD can reducing seizures by increasing A1R-mediated inhibition.
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Adenosine Kinase: Exploitation for Therapeutic Gain
TL;DR: This review will provide a comprehensive overview of the genetics, biochemistry, and pharmacology of ADK and will then focus on pathologies and therapeutic interventions.
Journal ArticleDOI
Adenosine kinase is a target for the prediction and prevention of epileptogenesis in mice
Tianfu Li,Gaoying Ren,Theresa A. Lusardi,Andrew Wilz,Jing Q. Lan,Takuji Iwasato,Shigeyoshi Itohara,Roger P. Simon,Detlev Boison +8 more
TL;DR: It is demonstrated that upregulation of ADK and spontaneous focal electroencephalographic seizures were both restricted to the affected CA3, and suggested that astrocyte-based ADK provides a critical link between astrogliosis and neuronal dysfunction in epilepsy.