Amine Noueiry

TL;DR: This work proposes a hierarchical mixture model to provide methodology that is both sensitive in detecting differential expression and sufficiently flexible to account for the complex variability of normalized microarray data.

TL;DR: This review focuses on host factors involved in positivestrand RNA virus genome replication, which encompass over one-third of all virus genera and include numerous pathogens, including numerous pathogens on the U.S. Health and Human Services Department Select List of potential bioterrorism agents.

TL;DR: E engineered BMV derivatives were used to assay viral RNA replication in each strain of an ordered, genome-wide set of yeast single-gene deletion mutants and nearly 100 genes whose absence inhibited or stimulated BMV RNA replication and/or gene expression were revealed.

TL;DR: This review addresses recent findings on the identification and characterization of host factors in BMV RNA replication, and characterizing the functions of these host factors is revealing basic aspects of virus RNA replication and helping to define the normal functions ofThese factors in the host.

TL;DR: It is shown that hepatitis C virus (HCV) RNA translation and replication depends on Rck/p54, LSm1, and PatL1, which regulate the fate of cellular mRNAs from translation to degradation in the 5′-3′-deadenylation-dependent mRNA decay pathway, which bridge HCV life cycle requirements and highly conserved host proteins of cellular mRNA decay.