Amir Huda

TL;DR: Biochemical changes in the white matter may provide some of the neurobiological substrates to late-life major depression.

TL;DR: To quantify the changes in brain water diffusivity in hepatic encephalopathy associated with cirrhosis using diffusion tensor imaging (DTI) and to correlate with neuropsychological (NP) scores.

TL;DR: The relationship of changes in the metabolite ratios recorded from a voxel in the posteromedial parietal lobe to the neuropsychologic findings before and after liver transplantation is a major finding.

TL;DR: This study partially confirms a hypothesized mechanism of HE pathogenesis, an increased synthesis of glutamine by brain glutamate in astrocytes due to excessive blood ammonia, followed by a compensatory loss of myo‐inositol to maintainAstrocyte volume homeostasis and indicates that the hyperintensity observed in globus pallidus could be used as complementary to the NP test scores in evaluating the mental health of HE patients.

TL;DR: Subclinical and low grade HE patients showed a significant reduction in mI/Cr and Cho/Cr ratio when compared with healthy control subjects and showed impairment in frontal lobe mediated cognitive tasks and in motor ability that were not appreciated in a bedside examination.