A
Amir Mehrkar
Researcher at University of Oxford
Publications - 100
Citations - 7177
Amir Mehrkar is an academic researcher from University of Oxford. The author has contributed to research in topics: Medicine & Population. The author has an hindex of 14, co-authored 44 publications receiving 3446 citations.
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Journal ArticleDOI
Factors associated with COVID-19-related death using OpenSAFELY.
Elizabeth A. Williamson,Alex J Walker,Krishnan Bhaskaran,Seb Bacon,Chris Bates,Caroline E Morton,Helen J Curtis,Amir Mehrkar,David M. Evans,Peter Inglesby,Jonathan Cockburn,Helen Mcdonald,Brian MacKenna,Laurie A. Tomlinson,Ian J. Douglas,Christopher T Rentsch,Rohini Mathur,Angel Y S Wong,Richard Grieve,David G. Harrison,Harriet Forbes,Anna Schultze,Richard Croker,John Parry,Frank Hester,Sam Harper,Rafael Perera,Stephen J. W. Evans,Liam Smeeth,Ben Goldacre +29 more
TL;DR: A range of clinical factors associated with COVID-19-related death is quantified in one of the largest cohort studies on this topic so far and includes people of white ethnicity, Black and South Asian people were at higher risk, even after adjustment for other factors.
Posted ContentDOI
OpenSAFELY: factors associated with COVID-19-related hospital death in the linked electronic health records of 17 million adult NHS patients
Elizabeth A. Williamson,Alex J Walker,Krishnan Bhaskaran,Seb Bacon,Chris Bates,Caroline E Morton,Helen J Curtis,Amir Mehrkar,David M. Evans,Peter Inglesby,Jonathan Cockburn,Helen Mcdonald,Brian MacKenna,Laurie A. Tomlinson,Ian J. Douglas,Christopher T Rentsch,Rohini Mathur,Angel Wong,Richard Grieve,David G. Harrison,Harriet Forbes,Anna Schultze,Richard Croker,John Parry,Frank Hester,Sam Harper,Rafael Perera,Stephen J. W. Evans,Liam Smeeth,Ben Goldacre +29 more
TL;DR: People from Asian and black groups are at markedly increased risk of in-hospital death from COVID-19, and contrary to some prior speculation this is only partially attributable to pre-existing clinical risk factors or deprivation; further research into the drivers of this association is therefore urgently required.
Journal ArticleDOI
Ethnic differences in SARS-CoV-2 infection and COVID-19-related hospitalisation, intensive care unit admission, and death in 17 million adults in England: an observational cohort study using the OpenSAFELY platform.
Rohini Mathur,Christopher T Rentsch,Caroline E Morton,William J Hulme,Anna Schultze,Brian MacKenna,Rosalind M Eggo,Krishnan Bhaskaran,Angel Y S Wong,Elizabeth A. Williamson,Harriet Forbes,Kevin Wing,Helen Mcdonald,Helen Mcdonald,Christopher M. Bates,Seb Bacon,Alex J Walker,David M. Evans,Peter Inglesby,Amir Mehrkar,Helen J Curtis,Nicholas J DeVito,Richard Croker,Henry Drysdale,Jonathan Cockburn,John Parry,Frank Hester,Sam Harper,Ian J. Douglas,Laurie A. Tomlinson,Stephen J. W. Evans,Richard Grieve,David G. Harrison,Kathy Rowan,Kamlesh Khunti,Nishi Chaturvedi,Liam Smeeth,Ben Goldacre +37 more
TL;DR: In this article, an observational cohort study of adults (aged ≥18 years) registered with primary care practices in England for whom electronic health records were available through the OpenSAFELY platform, and who had at least 1 year of continuous registration at the start of each study period (Feb 1 to Aug 3, 2020 [wave 1], and Sept 1 to Dec 31, 2020[wave 2]).
Journal ArticleDOI
HIV infection and COVID-19 death: a population-based cohort analysis of UK primary care data and linked national death registrations within the OpenSAFELY platform.
Krishnan Bhaskaran,Christopher T Rentsch,Brian MacKenna,Anna Schultze,Amir Mehrkar,Chris Bates,Rosalind M Eggo,Caroline E Morton,Sebastian Bacon,Peter Inglesby,Ian J. Douglas,Alex J Walker,Helen Mcdonald,Jonathan Cockburn,Elizabeth A. Williamson,David M. Evans,Harriet Forbes,Helen J Curtis,William J Hulme,John Parry,Frank Hester,Sam Harper,Stephen J. W. Evans,Stephen J. W. Evans,Liam Smeeth,Ben Goldacre +25 more
TL;DR: People with HIV in the UK seem to be at increased risk of COVID-19 mortality, and targeted policies should be considered to address this raised risk as the pandemic response evolves.
Journal ArticleDOI
Risk of COVID-19-related death among patients with chronic obstructive pulmonary disease or asthma prescribed inhaled corticosteroids: an observational cohort study using the OpenSAFELY platform.
Anna Schultze,Alex J Walker,Brian MacKenna,Caroline E Morton,Krishnan Bhaskaran,Jeremy P Brown,Christopher T Rentsch,Elizabeth Williamson,Henry Drysdale,Richard Croker,Seb Bacon,William J Hulme,Christopher M. Bates,Helen J Curtis,Amir Mehrkar,David M. Evans,Peter Inglesby,Jonathan Cockburn,Helen Mcdonald,Laurie A. Tomlinson,Rohini Mathur,Kevin Wing,Angel Y S Wong,Harriet Forbes,John Parry,Frank Hester,Sam Harper,Stephen J. W. Evans,Jennifer K Quint,Liam Smeeth,Ian J. Douglas,Ben Goldacre +31 more
TL;DR: The results do not support a major role for regular ICS use in protecting against COVID-19-related death among people with asthma or COPD, and the apparent harmful association observed can be plausibly explained by unmeasured confounding due to disease severity.