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Amr H. Sawalha
Researcher at University of Pittsburgh
Publications - 215
Citations - 9674
Amr H. Sawalha is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Systemic lupus erythematosus & DNA methylation. The author has an hindex of 52, co-authored 188 publications receiving 7794 citations. Previous affiliations of Amr H. Sawalha include University of Oklahoma Health Sciences Center & United States Department of Veterans Affairs.
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Journal ArticleDOI
Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus
Biola M. Javierre,Agustín F. Fernández,Julia Richter,Fatima Al-Shahrour,J. Ignacio Martin-Subero,Javier Rodríguez-Ubreva,María Berdasco,Mario F. Fraga,Terrance P. O'Hanlon,Lisa G. Rider,Filipe V. Jacinto,F. Javier López-Longo,Joaquín Dopazo,Marta Forn,Miguel A. Peinado,Luis Carreño,Amr H. Sawalha,John B. Harley,Reiner Siebert,Manel Esteller,Frederick W. Miller,Esteban Ballestar +21 more
TL;DR: The findings not only identify potentially relevant DNA methylation markers for the clinical characterization of SLE patients but also support the notion that epigenetic changes may be critical in the clinical manifestations of autoimmune disease.
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COVID-19 and autoimmune diseases.
TL;DR: In this article, the authors evaluated the relationship between infection with SARS-CoV-2 and autoimmunity, focusing on similarities in immune responses, cross-reactivity of SARS and CoV2, the development of autoimmune diseases in COVID-19 patients, and the risk of infection in patients with preexisting autoimmune conditions.
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Genome-wide DNA methylation study suggests epigenetic accessibility and transcriptional poising of interferon-regulated genes in naïve CD4+ T cells from lupus patients
Patrick Coit,Matlock A. Jeffries,Nezam Altorok,Mikhail G. Dozmorov,Kristi A. Koelsch,Jonathan D. Wren,Jonathan D. Wren,Joan T. Merrill,W. Joseph McCune,Amr H. Sawalha +9 more
TL;DR: The data suggest epigenetic "poising" of interferon-regulated genes in l upus naïve CD4+ T cells, argue for a novel pathogenic implication for abnormal T cell DNA methylation in lupus, and suggest a mechanism for type-I interferons hyper-responsiveness in lUPus T cells.
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Genome-wide DNA methylation patterns in CD4+ T cells from patients with systemic lupus erythematosus
Matlock A. Jeffries,Mikhail G. Dozmorov,Yuhong Tang,Joan T. Merrill,Jonathan D. Wren,Amr H. Sawalha,Amr H. Sawalha,Amr H. Sawalha +7 more
TL;DR: Data suggest that the methylation status of RAB22A, STX1B2, LGALS3BP, DNASE1L1 and PREX1 correlates with disease activity in lupus patients, and protein-protein interaction maps identified a transcription factor, HNF4a, as a regulatory hub affecting a number of differentially methylated genes.
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Epigenetic dysregulation of ACE2 and interferon-regulated genes might suggest increased COVID-19 susceptibility and severity in lupus patients.
TL;DR: It is suggested that patients with systemic lupus erythematous might be especially prone to severe COVID-19 independent of their immunosuppressed state from lupUS treatment, and Epigenetic control of the ACE2 gene might be a target for prevention and therapy in CO VID-19.