Amy Chadburn

TL;DR: It is found that clinical isolates of several types of B cell lymphomas, including diffuse large B Cell lymphoma (DLBCL), have 10- to 30-fold higher copy numbers of miR-155 than do normal circulating B cells, and the quantities of BIC RNA are elevated in lymphoma cells, but ratios of the amounts of the two RNAs are not constant, suggesting that the level of mi R-155 is controlled by transcription and processing.

TL;DR: It is recommended that these malignant lymphomas be designated primary effusion lymphomas (PEL), rather than body cavity-based lymphomas, since this term describes them more accurately and avoids their confusion with other malignant cancerous lymphomas that occur in the body cavities.

TL;DR: The posttransplantation lymphoproliferative disorders are divisible into three categories exhibiting distinct morphologic and molecular genetic characteristics and Alterations involving the N-ras and c-myc proto- oncogenes and the p53 tumor suppressor gene may play an important role in the development and/or progression of the PT-LPDs.

TL;DR: The addition of rituximab to CHOP in patients with HIV-NHL may be associated with improved tumor responses, however, these benefits may be offset by an increase in infectious deaths, particularly in those individuals with CD4(+) lymphocyte counts less than 50/mm(3).

TL;DR: In selected asymptomatic patients with MCL, deferred initial treatment ("watch and wait") is an acceptable management approach and time to treatment did not predict overall survival in a multivariate analysis.