Wayne Tam

TL;DR: A relatively small set of miRNAs, many of which are ubiquitously expressed, account for most of the differences in miRNA profiles between cell lineages and tissues.

TL;DR: It is found that clinical isolates of several types of B cell lymphomas, including diffuse large B Cell lymphoma (DLBCL), have 10- to 30-fold higher copy numbers of miR-155 than do normal circulating B cells, and the quantities of BIC RNA are elevated in lymphoma cells, but ratios of the amounts of the two RNAs are not constant, suggesting that the level of mi R-155 is controlled by transcription and processing.

TL;DR: Neutrophils around the marginal zone (MZ) of the spleen, a B cell area specialized in T cell–independent immunoglobulin responses to circulating antigen, are identified, which indicates that neutrophils generate an innate layer of antimicrobial immunoglOBulin defense by interacting with MZ B cells.

TL;DR: The engineered mice engineered in this work express BCL6 constitutively in B cells by mimicking a chromosomal translocation found in human DLBCL and develop a lymphoproliferative syndrome that culminates with the development of lymphomas displaying features typical of human DLBS.

TL;DR: It is shown that KMT2D functions as a bona fide tumor suppressor and that its genetic ablation in B cells promotes lymphoma development in mice and may promote malignant outgrowth by perturbing the expression of tumor suppressing genes that control B cell–activating pathways.