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Amy Nowack
Researcher at University of Washington
Publications - 16
Citations - 599
Amy Nowack is an academic researcher from University of Washington. The author has contributed to research in topics: Vestibular system & Semicircular canal. The author has an hindex of 10, co-authored 15 publications receiving 512 citations.
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Journal ArticleDOI
Cotrafficking of SV2 and synaptotagmin at the synapse
TL;DR: It is shown that a tyrosine-based endocytosis motif in the vesicle protein SV2 is required for trafficking to synaptic vesicles of both SV2 and the calcium sensor protein synaptotagmin.
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SV2 regulates neurotransmitter release via multiple mechanisms
TL;DR: Results indicate that SV2 performs at least two actions at the synapse that contribute to neurotransmitter release, and indicates an essential action of SV2 that is unrelated to its role in synaptotagmin expression or trafficking.
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Prosthetic implantation of the human vestibular system
Justin S. Golub,Leo Ling,Kaibao Nie,Amy Nowack,Sarah J. Shepherd,Steven M. Bierer,Elyse Jameyson,Chris R. S. Kaneko,James O. Phillips,Jay T. Rubinstein +9 more
TL;DR: Prosthetic implantation of the semicircular canals in humans is technically feasible and Preservation of native auditory and vestibular function was not demonstrated in a single subject with advanced Ménière’s disease.
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Levetiracetam Reverses Synaptic Deficits Produced by Overexpression of SV2A
TL;DR: It is reported that levetiracetam reverses the effects of excess SV2A in autaptic hippocampal neurons, and the results indicate that changes in SV2 expression in either direction impact neurotransmission, and suggest that the drug may modulate SV2 protein interactions.
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Vestibular implantation and longitudinal electrical stimulation of the semicircular canal afferents in human subjects
James O. Phillips,Leo Ling,Kaibao Nie,Elyse Jameyson,Christopher M. Phillips,Amy Nowack,Justin S. Golub,Jay T. Rubinstein +7 more
TL;DR: It is demonstrated that canal-specific two-dimensionally (2D) measured eye velocities are elicited from intermittent brief 2 s biphasic pulse electrical stimulation in four human subjects implanted with a Vestibular prosthesis, suggesting that electrical stimulation of the vestibular end organ in human subjects provided controlled vestibul inputs over time.