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Amy V. Kaucher
Researcher at Washington State University
Publications - 7
Citations - 595
Amy V. Kaucher is an academic researcher from Washington State University. The author has contributed to research in topics: Stem cell & Population. The author has an hindex of 6, co-authored 7 publications receiving 505 citations.
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Journal ArticleDOI
Functional and molecular features of the Id4+ germline stem cell population in mouse testes
Frieda Chan,Melissa J. Oatley,Amy V. Kaucher,Qi-En Yang,Charles J. Bieberich,Cooduvalli S. Shashikant,Jon M. Oatley +6 more
TL;DR: This work generated a transgenic mouse line in which spermatogonial stem cells are marked by expression of an inhibitor of differentiation 4 (Id4)-green fluorescent protein (Gfp) transgene, providing the first definitive evidence that stem cells exist as a rare subset of the type A(single) pool.
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MicroRNAs 221 and 222 regulate the undifferentiated state in mammalian male germ cells
TL;DR: It is found that impaired function of the X chromosome-clustered microRNAs 221 and 222 (miR-221/222) in mouse undifferentiated spermatogonia induces transition from a KIT– to a K IT+ state and loss of stem cell capacity to regenerate sperMatogenesis.
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Generation of germline ablated male pigs by CRISPR/Cas9 editing of the NANOS2 gene
Ki-Eun Park,Ki-Eun Park,Amy V. Kaucher,Anne M. Powell,Muhammad Salman Waqas,Shelley E. S. Sandmaier,Shelley E. S. Sandmaier,Melissa J. Oatley,Chi-Hun Park,Chi-Hun Park,Ahmed Tibary,David M. Donovan,Le Ann Blomberg,Simon G. Lillico,C. Bruce A. Whitelaw,Alan J. Mileham,Bhanu Prakash V.L. Telugu,Bhanu Prakash V.L. Telugu,Jon M. Oatley +18 more
TL;DR: It is found that NANOS2 knockout pigs phenocopy knockout mice with male specific germline ablation but other aspects of testicular development are normal and male pigs with one intact NANos2 allele and female knockout pigs are fertile.
Journal ArticleDOI
NEUROG3 Is a Critical Downstream Effector for STAT3-Regulated Differentiation of Mammalian Stem and Progenitor Spermatogonia
TL;DR: A mechanism by which activation of STAT3 regulates the expression of NEUROG3 to subsequently drive differentiation of SSC and progenitor spermatogonia in the mammalian germline is established.
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Conditions for Long-Term Culture of Cattle Undifferentiated Spermatogonia
TL;DR: Methodology for isolation of a cell fraction from prepubertal bull testes that is enriched for undifferentiated spermatogonia and long-term maintenance of the cells in both the feeder cell coculture and theFeeder-free format is described.