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Ana Fernandes-Platzgummer
Researcher at Instituto Superior Técnico
Publications - 41
Citations - 901
Ana Fernandes-Platzgummer is an academic researcher from Instituto Superior Técnico. The author has contributed to research in topics: Mesenchymal stem cell & Stromal cell. The author has an hindex of 14, co-authored 31 publications receiving 663 citations. Previous affiliations of Ana Fernandes-Platzgummer include University of Lisbon.
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Journal ArticleDOI
A xenogeneic-free bioreactor system for the clinical-scale expansion of human mesenchymal stem/stromal cells
Francisco dos Santos,Andrew Campbell,Ana Fernandes-Platzgummer,Pedro Z. Andrade,Jeffrey M. Gimble,Yuan Wen,Shayne Boucher,Mohan C. Vemuri,Cláudia Lobato da Silva,Joaquim M. S. Cabral +9 more
TL;DR: A xenogeneic (xeno)‐free microcarrier‐based culture system was successfully established for bone marrow (BM) MSC and adipose tissue‐derived stem/stromal cell (ASC) cultivation using a 1L‐scale controlled stirred‐tank bioreactor system under xeno‐free conditions.
Journal ArticleDOI
Delta One T Cells for Immunotherapy of Chronic Lymphocytic Leukemia: Clinical-Grade Expansion/Differentiation and Preclinical Proof of Concept
Afonso Rm Almeida,Daniel V. Correia,Ana Fernandes-Platzgummer,Cláudia Lobato da Silva,Maria Gomes da Silva,Maria Gomes da Silva,Anjos Diogo Antonio Remechido,Bruno Silva-Santos +7 more
TL;DR: A clinical-grade method and the preclinical proof of principle for application of a new cellular product, DOT cells, in adoptive immunotherapy of CLL are provided.
Journal ArticleDOI
Scalable Production of Human Mesenchymal Stromal Cell-Derived Extracellular Vesicles Under Serum-/Xeno-Free Conditions in a Microcarrier-Based Bioreactor Culture System
Miguel de Almeida Fuzeta,Miguel de Almeida Fuzeta,Nuno Bernardes,Filipa D. Oliveira,Ana Costa,Ana Fernandes-Platzgummer,José Paulo S. Farinha,Carlos A V Rodrigues,Sunghoon Jung,Rong-Jeng Tseng,William Milligan,Brian Lee,Miguel A. R. B. Castanho,Diana Gaspar,Joaquim M. S. Cabral,Cláudia Lobato da Silva +15 more
TL;DR: It is demonstrated that this scalable culture system can robustly manufacture EVs from MSC derived from different tissue sources, toward the development of novel therapeutic products.
Journal ArticleDOI
Scalable microcarrier-based manufacturing of mesenchymal stem/stromal cells.
TL;DR: A comprehensive overview on the scalable manufacturing of human mesenchymal stem/stromal cells is provided, depicting the various steps involved in the process from cell isolation to ex vivo expansion, using different cell tissue sources and culture medium formulations and exploiting bioprocess engineering tools namely microcarrier technology and bioreactors.
Journal ArticleDOI
Stirred tank bioreactor culture combined with serum-/xenogeneic-free culture medium enables an efficient expansion of umbilical cord-derived mesenchymal stem/stromal cells.
Amanda Mizukami,Ana Fernandes-Platzgummer,Joana G. Carmelo,Kamilla Swiech,Dimas Tadeu Covas,Joaquim M. S. Cabral,Cláudia Lobato da Silva +6 more
TL;DR: The development of a scalable microcarrier-based stirred culture system, using xeno-free culture medium that suits the intrinsic features of UCM-derived MSC represents an important step towards a GMP compliant large-scale production platform for these promising cell therapy candidates.