Ana Torres

TL;DR: CCR7 activates two independent signaling modules, one involving Gi and a hierarchy of MAPK family members and another involving Rho/Pyk2/cofilin, which control, respectively, chemotaxis and the migratory speed of DCs.

TL;DR: The conclusion is that the cooperation between NO and Immunosuppressors that induce apoptosis in PTEC might contribute to the renal toxicity observed in the course of immunosuppressive therapy.

TL;DR: It is suggested that the affinity of cilastatin for renal dipeptidase makes this effect specific for proximal tubular cells and may be related to a reduction in intracellular drug accumulation.

TL;DR: MPTP kinetics and cyto-c release are abnormal in skeletal and respiratory muscles of patients with moderate COPD, suggesting a systemic mechanism(s) occurring early during the course of the disease.

TL;DR: Preventing CyA-induced reduction of cell membrane fluidity and inhibition of CyA transport are features of cilastatin's direct effects on PTECs, and unaltered distribution of MBCRs in the presence of cILastatin suggests that cilastsatin binding to raft-bound dipeptidases, rather than MBCR modifications, causes interference withCyA transport.