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Anant B. Parekh
Researcher at University of Oxford
Publications - 124
Citations - 9938
Anant B. Parekh is an academic researcher from University of Oxford. The author has contributed to research in topics: Voltage-dependent calcium channel & Calcium signaling. The author has an hindex of 43, co-authored 120 publications receiving 9455 citations. Previous affiliations of Anant B. Parekh include Max Planck Society & Nagoya University.
Papers
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Journal ArticleDOI
Store-operated calcium channels.
Anant B. Parekh,James W. Putney +1 more
TL;DR: The key electrophysiological features of I(CRAC) and other store-operated Ca(2+) currents and how they are regulated are described, and recent advances that have shed insight into the molecular mechanisms involved in this ubiquitous and vital Ca( 2+) entry pathway are considered.
Journal ArticleDOI
Store depletion and calcium influx
Anant B. Parekh,Reinhold Penner +1 more
TL;DR: The electrophysiological properties of the prototype store-operated current ICRAC are focused on, the regulatory mechanisms that control it are discussed, and recent advances toward the identification of molecular mechanisms involved in this ubiquitous and important Ca2+ entry pathway are considered.
Journal ArticleDOI
Depletion of InsP3 stores activates a Ca2+ and K+ current by means of a phosphatase and a diffusible messenger
TL;DR: The nature of this influx pathway is investigated and a current activated by pool depletion is found that has an unusual selectivity in that it is more permeable to Ca2+ ions than to other divalent cations (Ba2+, Sr2+ or Mn2+ ).
Journal ArticleDOI
Store-operated CRAC channels: function in health and disease
TL;DR: Recent advances in understanding the gating and function of CRAC channels, their links to human disease and key issues for the development of channel blockers are summarized.
Journal ArticleDOI
The store-operated calcium current icrac : nonlinear activation by insp3 and dissociation from calcium release
TL;DR: Patch-clamp experiments aimed at determining the relationship between intracellular Ca2+ release and activation of store-operated calcium current I( CRAC) reveal that both agonist and InsP3-mediated activation of I(CRAC) are highly nonlinear, occurring over a narrow concentration range.