Anders Björkman

TL;DR: Following deployment of ACT in Zanzibar 2003, malaria-associated morbidity and mortality decreased dramatically within two years and indicated that the Millennium Development Goals of reducing mortality in children under five and alleviating the burden of malaria are achievable in tropical Africa with high coverage of combined malaria control interventions.

TL;DR: An follow-up clinical trial in Zanzibar points to 86N as a potential marker of lumefantrine resistance in vivo, while suggesting that Coartem is not robust enough to avoid selection of resistance-associated mutations in some malarial settings.

TL;DR: Data show that CYP2C8 is the main hepatic isoform responsible for the metabolism of AQ, and the specificity, high affinity, and high turnover make AQ desethylation an excellent marker reaction for CYP1C8 activity.

TL;DR: The results of the IFA and of an enzyme-linked immunosorbent assay were well-correlated, suggesting that the same antibodies were detected by these assays, and conclude that the antigens involved in these reactions are released from bursting schizonts or merozoites and are deposited in the E membrane in the course of invasion.

TL;DR: In the eight children harboring P. falciparum throughout the study period, infections were found to be highly complex with daily changes in both parasite density and genotypic pattern, and 48-hr periodicity in these fluctuations suggests that P. Falconerum infections consist of inherently synchronous subpopulations of parasites.