J
José Pedro Gil
Researcher at Karolinska Institutet
Publications - 81
Citations - 3439
José Pedro Gil is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Plasmodium falciparum & Malaria. The author has an hindex of 32, co-authored 76 publications receiving 3089 citations. Previous affiliations of José Pedro Gil include University of Maryland, Baltimore & Universidade Nova de Lisboa.
Papers
More filters
Journal ArticleDOI
In Vivo Selection of Plasmodium falciparum pfmdr1 86N Coding Alleles by Artemether-Lumefantrine (Coartem)
Christin Sisowath,Johan Strömberg,Andreas Mårtensson,Mwinyi I. Msellem,Christine Obondo,Anders Björkman,José Pedro Gil +6 more
TL;DR: An follow-up clinical trial in Zanzibar points to 86N as a potential marker of lumefantrine resistance in vivo, while suggesting that Coartem is not robust enough to avoid selection of resistance-associated mutations in some malarial settings.
Journal ArticleDOI
In vivo selection of Plasmodium falciparum parasites carrying the chloroquine-susceptible pfcrt K76 allele after treatment with artemether-lumefantrine in Africa
Christin Sisowath,Ines Petersen,M. Isabel Veiga,Andreas Mårtensson,Zul Premji,Anders Björkman,David A. Fidock,José Pedro Gil +7 more
TL;DR: The findings suggest that the pfcrt K76T mutation is a drug-specific contributor to enhanced P. falciparum susceptibility to lumefantrine in vivo and in vitro, and they highlight the benefit of using AL in areas affected by chloroquine-resistant P. Falconerum malaria.
Journal ArticleDOI
Amodiaquine resistant Plasmodium falciparum malaria in vivo is associated with selection of pfcrt 76T and pfmdr1 86Y.
Gabrielle Holmgren,José Pedro Gil,Pedro M. Ferreira,Pedro M. Ferreira,Maria Isabel Veiga,Maria Isabel Veiga,Charles O Obonyo,Anders Björkman +7 more
TL;DR: The study showed high prevalence of AQ resistant parasites in vivo, which appeared to be associated to pfcrt 76T and pfmdr1 86Y in recurrent infections and to the blood concentration of desethylamodiaquine (DEAQ).
Journal ArticleDOI
The role of pfmdr1 in Plasmodium falciparum tolerance to artemether-lumefantrine in Africa.
Christin Sisowath,Pedro Eduardo Ferreira,Pedro Eduardo Ferreira,Leyla Y. Bustamante,Sabina Dahlström,Andreas Mårtensson,Anders Björkman,Sanjeev Krishna,José Pedro Gil,José Pedro Gil +9 more
TL;DR: This study searched for the selection of other mutations potentially involved in artemether‐lumefantrine tolerance and/or resistance, i.e. pfmdr1 gene amplification, pfmDr1 Y184F, S1034C, N1042D, D1246Y, pfcrt S163R and PfATP6 S769N.
Journal ArticleDOI
Selection of pfmdr1 mutations after amodiaquine monotherapy and amodiaquine plus artemisinin combination therapy in East Africa.
Gabrielle Holmgren,Johan Hamrin,Jenny Svärd,Andreas Mårtensson,José Pedro Gil,José Pedro Gil,Anders Björkman +6 more
TL;DR: In this paper, the authors studied if mutations in the pfcrt and pfmdr1 genes selected in recurrent infections after AQ monotherapy are also selected after AQ plus ART combination therapy and found that ART may protect against a selection of these SNPs initially, but not after continuous drug pressure in a population.