A
Andrea Cassingena
Researcher at University of Milan
Publications - 30
Citations - 3702
Andrea Cassingena is an academic researcher from University of Milan. The author has contributed to research in topics: Colorectal cancer & KRAS. The author has an hindex of 18, co-authored 28 publications receiving 2870 citations. Previous affiliations of Andrea Cassingena include University of Turin.
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Journal ArticleDOI
Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients
Giulia Siravegna,Benedetta Mussolin,Michela Buscarino,Giorgio Corti,Andrea Cassingena,Giovanni Crisafulli,Agostino Ponzetti,Chiara Cremolini,Alessio Amatu,Calogero Lauricella,Simona Lamba,Sebastijan Hobor,Antonio Avallone,Emanuele Valtorta,Giuseppe Rospo,Enzo Medico,Valentina Motta,Carlotta Antoniotti,Fabiana Tatangelo,Beatriz Bellosillo,Silvio Veronese,Alfredo Budillon,Clara Montagut,Patrizia Racca,Silvia Marsoni,Alfredo Falcone,Ryan B. Corcoran,Federica Di Nicolantonio,Fotios Loupakis,Salvatore Siena,Andrea Sartore-Bianchi,Alberto Bardelli +31 more
TL;DR: The results indicate that the CRC genome adapts dynamically to intermittent drug schedules and provide a molecular explanation for the efficacy of rechallenge therapies based on EGFR blockade.
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Dual-targeted therapy with trastuzumab and lapatinib in treatment-refractory, KRAS codon 12/13 wild-type, HER2-positive metastatic colorectal cancer (HERACLES): A proof-of-concept, multicentre, open-label, phase 2 trial
Andrea Sartore-Bianchi,Livio Trusolino,Cosimo Martino,Katia Bencardino,Sara Lonardi,Francesca Bergamo,Vittorina Zagonel,Francesco Leone,Ilaria Depetris,Erika Martinelli,Teresa Troiani,Fortunato Ciardiello,Patrizia Racca,Andrea Bertotti,Giulia Siravegna,Valter Torri,Alessio Amatu,Silvia Ghezzi,Giovanna Marrapese,Laura Palmeri,Emanuele Valtorta,Andrea Cassingena,Calogero Lauricella,Angelo Vanzulli,Daniele Regge,Silvio Veronese,Paolo M. Comoglio,Alberto Bardelli,Silvia Marsoni,Salvatore Siena +29 more
TL;DR: The combination of trastuzumab and lapatinib is active and well tolerated in treatment-refractory patients with HER2-positive metastatic colorectal cancer.
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Amplification of the MET Receptor Drives Resistance to Anti-EGFR Therapies in Colorectal Cancer
Alberto Bardelli,Simona Corso,Andrea Bertotti,Sebastijan Hobor,Emanuele Valtorta,Giulia Siravegna,Andrea Sartore-Bianchi,Elisa Scala,Andrea Cassingena,Davide Zecchin,Maria Apicella,Giorgia Migliardi,Francesco Galimi,Calogero Lauricella,Carlo Zanon,Timothy Perera,Silvio Veronese,Giorgio Corti,Alessio Amatu,Marcello Gambacorta,Luis A. Diaz,Mark Sausen,Victor Velculescu,Paolo M. Comoglio,Livio Trusolino,Federica Di Nicolantonio,Silvia Giordano,Salvatore Siena +27 more
TL;DR: The role of MET in mediating primary and secondary resistance to anti-EGFR therapies in colorectal cancer is highlighted and the use of MET inhibitors in patients displaying resistance as a result of MET amplification is encouraged.
Journal ArticleDOI
The genomic landscape of response to EGFR blockade in colorectal cancer
Andrea Bertotti,Eniko Papp,Siân Jones,Vilmos Adleff,Valsamo Anagnostou,Barbara Lupo,Mark Sausen,Jillian Phallen,Carolyn Hruban,Collin Tokheim,Noushin Niknafs,Monica Nesselbush,Karli Lytle,Francesco Sassi,Francesca Cottino,Giorgia Migliardi,Eugenia R. Zanella,Dario Ribero,Nadia Russolillo,A. Mellano,Andrea Muratore,Gianluca Paraluppi,Mauro Salizzoni,Silvia Marsoni,Michael Kragh,Johan Lantto,Andrea Cassingena,Qing Kay Li,Rachel Karchin,Robert B. Scharpf,Andrea Sartore-Bianchi,Salvatore Siena,Luis A. Diaz,Livio Trusolino,Victor E. Velculescu +34 more
TL;DR: A systematic approach to evaluating response to targeted therapies in human cancer is provided, new mechanisms of responsiveness to anti-EGFR therapies are highlighted, and new avenues for intervention in managing colorectal cancer are delineated.
Journal ArticleDOI
Discovery of methylated circulating DNA biomarkers for comprehensive non-invasive monitoring of treatment response in metastatic colorectal cancer
Ludovic Barault,Alessio Amatu,Giulia Siravegna,Agostino Ponzetti,Sebastian Moran,Andrea Cassingena,Benedetta Mussolin,Chiara Falcomatà,Alexandra M. Binder,Carmen Cristiano,Daniele Oddo,Simonetta Guarrera,Carlotta Cancelliere,Sara Bustreo,Katia Bencardino,Sean K. Maden,Alice Vanzati,Patrizia Zavattari,Giuseppe Matullo,Mauro Truini,William M. Grady,Patrizia Racca,Karin B. Michels,Salvatore Siena,Manel Esteller,Alberto Bardelli,Andrea Sartore-Bianchi,Federica Di Nicolantonio +27 more
TL;DR: This five-gene methylation panel can be used to circumvent the absence of patient-specific mutations for monitoring tumour burden dynamics in liquid biopsy under different therapeutic regimens.