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Andrea J. Tenner
Researcher at University of California, Irvine
Publications - 167
Citations - 14706
Andrea J. Tenner is an academic researcher from University of California, Irvine. The author has contributed to research in topics: Complement system & Classical complement pathway. The author has an hindex of 64, co-authored 152 publications receiving 13110 citations. Previous affiliations of Andrea J. Tenner include American Red Cross & Oak Ridge National Laboratory.
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C5aR1 antagonism alters microglial polarization and mitigates disease progression in a mouse model of Alzheimer’s disease
Angela Gomez-Arboledas,Klébea Carvalho,Gabriela Balderrama-Gutierrez,Shu-Hui Chu,H. Liang,Nicole D. Schartz,Purnika Selvan,Tiffany J. Petrisko,Miranda A. Pan,Ali Mortazavi,Andrea J. Tenner +10 more
TL;DR: In this article , using PMX205, a potent, specific C5aR1 antagonist, in the Tg2576 mouse model of Alzheimer's disease, they show a striking reduction in dystrophic neurites in parallel with the reduced amyloid load, rescue of the excessive pre-synaptic loss associated with AD cognitive impairment and the polarization of microglial gene expression towards a DAM-like phenotype that are consistent with the neuroprotective effects seen.
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Degenerate mapping of environmental location presages deficits in object-location encoding and memory in the 5xFAD mouse model for Alzheimer’s disease
Hai Zhang,Lujia Chen,Kevin G. Johnston,Joshua Crapser,Kim N. Green,N. Ha,Andrea J. Tenner,Todd C. Holmes,Douglas A. Nitz,Xiangmin Xu +9 more
TL;DR: In this article , the authors examined the temporal relationships between pathology, neuronal activities and spatial representation of environments, as well as object location memory deficits across multiple stages of development in the 5xFAD mice model and compared these results to those observed in wild-type mice.
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